| Basic Information | |
|---|---|
| Species | Citrus clementina |
| Cazyme ID | Ciclev10030724m |
| Family | GH89 |
| Protein Properties | Length: 812 Molecular Weight: 92624.6 Isoelectric Point: 6.5559 |
| Chromosome | Chromosome/Scaffold: 4 Start: 24971612 End: 24979659 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 92 | 802 | 0 |
| PEITIKGTTAVEITSGLHWYIKYWCGAHVSWEKTGGFQIASVPKPGSLPHVTDGGVKIQRPVPWNYYQNVVTSSYSYVWWEWERWEKEIDWMALQGINLP LAFNGQEAIWQKVFMNFNVTMEDLNDFFSGPAFLAWARMGNLHGWGGPLAQNWLNQQLVLQKKIVSRMLELGMTPVLPSFAGNVPAALKKIFPSANITRL GDWNTVDRNPRWCCTYLLDPTDPLFVEIGEAFIKQQIAEYGDVTDIYNCDSFNENTPPTNDTNYISSLGAAVYKAMSEGDKDAVWLMQGWLFYSDSAFWK PPQMKALLHSVPLGKMIVLDLFAEVKPIWRTSSQFYGAPYVWCMLHNFGGNIEIYGILDSIASGPVDARVSENSTMVGVGMCMEGIEQNPVVYELMSEMA FRNEKVQVLEWLKTYAHRRYGKAVPEVEATWEILYHTVYNCTDGIADHNTDFIVKFPDWDPSLHSGSAISKRDQMHALHALPGPRRFLSEENSDMPQAHL WYSNQELIKGLKLFLNAGNALAGSATYRYDLVDITRQALSKLANQVYMDAVIAFQHKDASAFNNHSQKFLQLIKDIDELLASNDNFLLGTWLESAKKLAT NPSEMIQYEYNARTQVTMWYDTNITTQSKLHDYANKFWSGLLVDYYLPRASTYFDYMSKSLREKSEFQVDRWRQQWVFISISWQSNWKTGTKNYPIRAKG DSIAIAKVLYD | |||
| Full Sequence |
|---|
| Protein Sequence Length: 812 Download |
| MSSLNLLFFV LIFTALPHPF VSKLEGIDVL LDRLDSKRVN SSVQESAAKA VLQRLLPTHV 60 NSFHFKIVSK DVCGGSSCFL IDNYKRTSQN EPEITIKGTT AVEITSGLHW YIKYWCGAHV 120 SWEKTGGFQI ASVPKPGSLP HVTDGGVKIQ RPVPWNYYQN VVTSSYSYVW WEWERWEKEI 180 DWMALQGINL PLAFNGQEAI WQKVFMNFNV TMEDLNDFFS GPAFLAWARM GNLHGWGGPL 240 AQNWLNQQLV LQKKIVSRML ELGMTPVLPS FAGNVPAALK KIFPSANITR LGDWNTVDRN 300 PRWCCTYLLD PTDPLFVEIG EAFIKQQIAE YGDVTDIYNC DSFNENTPPT NDTNYISSLG 360 AAVYKAMSEG DKDAVWLMQG WLFYSDSAFW KPPQMKALLH SVPLGKMIVL DLFAEVKPIW 420 RTSSQFYGAP YVWCMLHNFG GNIEIYGILD SIASGPVDAR VSENSTMVGV GMCMEGIEQN 480 PVVYELMSEM AFRNEKVQVL EWLKTYAHRR YGKAVPEVEA TWEILYHTVY NCTDGIADHN 540 TDFIVKFPDW DPSLHSGSAI SKRDQMHALH ALPGPRRFLS EENSDMPQAH LWYSNQELIK 600 GLKLFLNAGN ALAGSATYRY DLVDITRQAL SKLANQVYMD AVIAFQHKDA SAFNNHSQKF 660 LQLIKDIDEL LASNDNFLLG TWLESAKKLA TNPSEMIQYE YNARTQVTMW YDTNITTQSK 720 LHDYANKFWS GLLVDYYLPR ASTYFDYMSK SLREKSEFQV DRWRQQWVFI SISWQSNWKT 780 GTKNYPIRAK GDSIAIAKVL YDKYFGQQLI K* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam12971 | NAGLU_N | 4.0e-22 | 44 | 140 | 97 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
| pfam12972 | NAGLU_C | 4.0e-102 | 501 | 804 | 304 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam05089 | NAGLU | 0 | 157 | 496 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 6 | 805 | 70 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 44 | 805 | 56 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| RefSeq | NP_196873.1 | 0 | 27 | 805 | 28 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 6 | 805 | 5 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 21 | 806 | 23 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 35 | 804 | 162 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
| PDB | 2vcb_A | 0 | 35 | 804 | 162 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
| PDB | 2vca_A | 0 | 35 | 804 | 162 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
| PDB | 2vc9_A | 0 | 35 | 804 | 162 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 35 | 804 | 185 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
