y
Basic Information | |
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Species | Citrus clementina |
Cazyme ID | Ciclev10033641m |
Family | GH79 |
Protein Properties | Length: 499 Molecular Weight: 55492.8 Isoelectric Point: 6.5968 |
Chromosome | Chromosome/Scaffold: 4 Start: 24316998 End: 24319189 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 16 | 492 | 0 |
DDNFVCATIDWWPINKCDYNQCPWGKSGVLNLDLKNKILSNAIKAFQPLRIRVGGSLQDQVLYKVGNSAKKCPHFKLRKDGLFGFSKGCLSMNRWDEIND LFNQTGAVMTFGLNALIGRKKSKTDDTLWEGDWNAQNARDLMKYTISKGYKIESYELGNELCASGVSAKVSAEQYAKDIVALKNLVREMYPDATTQPKVL GPAGFFDKQWFNTFLEKSGQDVVDGLTHHIYNLGPGNDPELINRIQDPYYLDQIAQTYKDISETVKEFGPWSGAWVGEAGGAFNSGGKYVSHTFADGFWF LDQLGMTSTFNHKVFCRQALIGGNYALLNTTTFIPNPDYYGSLLWHRLMGKNVLATTQNASPYLRVYSHCSKEKPGITVLLINLSNSTSFDVSVINDMNL YPSQEQTQDSQDEKPREEYHLTPEGGNIQSDVVLLNGTPLKLTNSLDIPSMEPKLADRYSPITVAPHSIVFATLRDF |
Full Sequence |
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Protein Sequence Length: 499 Download |
DVKVTVQGVT SIANTDDNFV CATIDWWPIN KCDYNQCPWG KSGVLNLDLK NKILSNAIKA 60 FQPLRIRVGG SLQDQVLYKV GNSAKKCPHF KLRKDGLFGF SKGCLSMNRW DEINDLFNQT 120 GAVMTFGLNA LIGRKKSKTD DTLWEGDWNA QNARDLMKYT ISKGYKIESY ELGNELCASG 180 VSAKVSAEQY AKDIVALKNL VREMYPDATT QPKVLGPAGF FDKQWFNTFL EKSGQDVVDG 240 LTHHIYNLGP GNDPELINRI QDPYYLDQIA QTYKDISETV KEFGPWSGAW VGEAGGAFNS 300 GGKYVSHTFA DGFWFLDQLG MTSTFNHKVF CRQALIGGNY ALLNTTTFIP NPDYYGSLLW 360 HRLMGKNVLA TTQNASPYLR VYSHCSKEKP GITVLLINLS NSTSFDVSVI NDMNLYPSQE 420 QTQDSQDEKP REEYHLTPEG GNIQSDVVLL NGTPLKLTNS LDIPSMEPKL ADRYSPITVA 480 PHSIVFATLR DFKAPACA* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 1 | 320 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 497 | 26 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 497 | 24 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 498 | 25 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 2 | 496 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00000000000004 | 30 | 77 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000002 | 66 | 383 | 75 | 383 | A Chain A, Crystal Structure Of Galactosyltransferase Lgtc In Complex With Mn And Udp-2f-Galactose |
PDB | 3vnz_A | 0.000002 | 66 | 383 | 75 | 383 | A Chain A, Crystal Structure Of Galactosyltransferase Lgtc In Complex With Mn And Udp-2f-Galactose |
PDB | 3vny_A | 0.000002 | 66 | 383 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
JK986839 | 278 | 192 | 469 | 0 |
GR118344 | 261 | 73 | 333 | 0 |
GR072627 | 265 | 217 | 481 | 0 |
AJ805815 | 236 | 176 | 411 | 0 |
GO873410 | 322 | 15 | 336 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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