| Basic Information | |
|---|---|
| Species | Chlamydomonas reinhardtii |
| Cazyme ID | Cre09.g414250.t1.3 |
| Family | GT57 |
| Protein Properties | Length: 620 Molecular Weight: 65201.1 Isoelectric Point: 10.1061 |
| Chromosome | Chromosome/Scaffold: 9 Start: 7534122 End: 7537689 |
| Description | ALG6, ALG8 glycosyltransferase family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT57 | 19 | 125 | 0 |
| ATAVKLLLLPTYRSTDFEVHRNWLAITHSLPLSKWYVDATSVWTLDYPPLFAWFEWALSQAAAAVDPAMLRVVNLDHDSAATVAFQRGSVIVTDLVLLLA AFWLARD | |||
| GT57 | 178 | 595 | 0 |
| RGVALFALLALNAGLLLVDHIHFQYNGAMMGVLLLSLAAARTGRHLLSGVLFAVLLNMKHLFLFAAPVYFVYLLRHYCFETTGGSSSSGSSGAQGNWAAR GLTRLAVLGAAVIAVFAASFGPFVALGQIPQVFGRLFPFGRGLLHAYWAANAWAPYAAADKLLVLAAPALNRQLGWAALRVDAEAVGSANLAGGLVKVQR FAVLPQITPSITAAAVLMALVPCLVGLWRLGRAAGHVAVGPGAAPASSRQHVRRVFARALAYSCLCGFVFGWHVHEKAIIVALLPLAVDAVCSRLAARRF LVLSTAGHYGLLPLLFRPEEYGTKVLLVASYFAVAATALGALHGDAASPHARAARTGGKRNAGLALGWLQRAYLVGFVAVELYCSVVHERVPALRERLPF APLMLTSVYCSLGVLGVW | |||
| Full Sequence |
|---|
| Protein Sequence Length: 620 Download |
| MVIKHGSFGV LCLQLAVVAT AVKLLLLPTY RSTDFEVHRN WLAITHSLPL SKWYVDATSV 60 WTLDYPPLFA WFEWALSQAA AAVDPAMLRV VNLDHDSAAT VAFQRGSVIV TDLVLLLAAF 120 WLARDVAATG VASGGGGGSG IFSGPASSGS RAAPPRSTSF SGLPVDSRSS AAALAGRRGV 180 ALFALLALNA GLLLVDHIHF QYNGAMMGVL LLSLAAARTG RHLLSGVLFA VLLNMKHLFL 240 FAAPVYFVYL LRHYCFETTG GSSSSGSSGA QGNWAARGLT RLAVLGAAVI AVFAASFGPF 300 VALGQIPQVF GRLFPFGRGL LHAYWAANAW APYAAADKLL VLAAPALNRQ LGWAALRVDA 360 EAVGSANLAG GLVKVQRFAV LPQITPSITA AAVLMALVPC LVGLWRLGRA AGHVAVGPGA 420 APASSRQHVR RVFARALAYS CLCGFVFGWH VHEKAIIVAL LPLAVDAVCS RLAARRFLVL 480 STAGHYGLLP LLFRPEEYGT KVLLVASYFA VAATALGALH GDAASPHARA ARTGGKRNAG 540 LALGWLQRAY LVGFVAVELY CSVVHERVPA LRERLPFAPL MLTSVYCSLG VLGVWGDIAF 600 EWSGEALGYP SRSSFGADT* 660 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03155 | Alg6_Alg8 | 7.0e-29 | 28 | 119 | 100 | + ALG6, ALG8 glycosyltransferase family. N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147. | ||
| pfam03155 | Alg6_Alg8 | 2.0e-58 | 195 | 596 | 402 | + ALG6, ALG8 glycosyltransferase family. N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAH90105.1 | 0 | 15 | 598 | 22 | 515 | alg8-prov protein [Xenopus (Silurana) tropicalis] |
| RefSeq | NP_001017647.1 | 0 | 15 | 591 | 15 | 500 | dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Danio rerio] |
| RefSeq | NP_001076820.1 | 0 | 15 | 598 | 32 | 525 | dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Xenopus (Silurana) tropicalis] |
| RefSeq | NP_001084808.1 | 0 | 15 | 595 | 35 | 525 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog [Xenopus laevis] |
| RefSeq | XP_001696729.1 | 0 | 19 | 595 | 1 | 518 | glycosyl transferase, type ALG6, ALG8 [Chlamydomonas reinhardtii] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| dolichyl-diphosphooligosaccharide biosynthesis | RXN-5471 | EC-2.4.1.265 | Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase |
