| Basic Information | |
|---|---|
| Species | Cucumis sativus |
| Cazyme ID | Cucsa.077120.1 |
| Family | GT47 |
| Protein Properties | Length: 459 Molecular Weight: 52335.2 Isoelectric Point: 9.5402 |
| Chromosome | Chromosome/Scaffold: 00791 Start: 219995 End: 223032 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 83 | 381 | 0 |
| LSLKIYVYDETEIQGLKALMYGRDGKITAAACLKGQWGTQVKIHRLLLQSRFRTRNKEEADFFFVPAYVKCVRMLGGLNDKEINEAYIQVLGQMPYFRLS GGRDHIFVFPSGAGAHLFKSWATYINRSIILTPEGDRTDKKDFSAFNTWKDIIIPGNVDDGMTSPGAKIVQPLPLSKRKHLANYLGRDQGKVGRLKLIEL AKQFPEKLESPVLKFSGPDKLGKLEYFEHLRNAKFCLAPRGESSWTLRFYESFFVECVPVVLSDQVELPFQNVIDYSQISIKWPSSEIGPQLLEYLESI | |||
| Full Sequence |
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| Protein Sequence Length: 459 Download |
| MGSVNNKGRP FGAHHNPPLC TRSHQIGALL LVCTTFFLTR AFDRLLVPFS PNSFSGFRQS 60 HYALQSNHDG SISWPDRGYG SHLSLKIYVY DETEIQGLKA LMYGRDGKIT AAACLKGQWG 120 TQVKIHRLLL QSRFRTRNKE EADFFFVPAY VKCVRMLGGL NDKEINEAYI QVLGQMPYFR 180 LSGGRDHIFV FPSGAGAHLF KSWATYINRS IILTPEGDRT DKKDFSAFNT WKDIIIPGNV 240 DDGMTSPGAK IVQPLPLSKR KHLANYLGRD QGKVGRLKLI ELAKQFPEKL ESPVLKFSGP 300 DKLGKLEYFE HLRNAKFCLA PRGESSWTLR FYESFFVECV PVVLSDQVEL PFQNVIDYSQ 360 ISIKWPSSEI GPQLLEYLES IPDETIDKMI ARGRRVRCLW VYASDSEPCS TMQGILWELQ 420 RKVRQFHQST ETFWLHNGSF VNRQLVEFSK WKPPMPLP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 6.0e-43 | 85 | 381 | 311 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_564141.1 | 0 | 4 | 458 | 5 | 462 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002265632.1 | 0 | 1 | 458 | 1 | 459 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002300942.1 | 0 | 1 | 458 | 1 | 460 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002307477.1 | 0 | 1 | 458 | 1 | 460 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002526175.1 | 0 | 1 | 458 | 1 | 453 | catalytic, putative [Ricinus communis] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| CX668832 | 291 | 145 | 435 | 0 |
| AM721020 | 265 | 1 | 265 | 0 |
| FE707914 | 279 | 125 | 403 | 0 |
| FE707913 | 274 | 186 | 459 | 0 |
| HO781282 | 324 | 19 | 342 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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