y
Basic Information | |
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Species | Cucumis sativus |
Cazyme ID | Cucsa.128090.1 |
Family | GH89 |
Protein Properties | Length: 775 Molecular Weight: 88320 Isoelectric Point: 7.4071 |
Chromosome | Chromosome/Scaffold: 01024 Start: 200484 End: 216165 |
Description | alpha-N-acetylglucosaminidase family / NAGLU family |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH89 | 91 | 771 | 0 |
AEILIRGTTAVEITSGLYWYLKYWCGAHVSWDKTGGVQLASIPKPGSLPFLKGNGVVIKRPVPWNYYQNVVTSSYSYVWWDWERWEKEIDWMALHGINLP LAFTGQESIWRNVFRDFNLAVKDLDNFFGGPAFLAWARMGNLHGWGGPLSKNWLDQQLALQKQILSRMRELGMTPVLPSFSGNVPAGLVEIFPSANITKL GNWNSIDADPSTCCTYLLNPSDPLFVKIGEAFIRQQIKEYGDVTNIYSCDTFNENTPPTNDTSYISSLGASVYKAMVKADKDAVWLMQGWLFYSDSDFWK PDQMKALLHSVPFGKMIVLDLFADVKPIWKSSSQFYGTPYVWCMLHNFGGNIEMYGILDAISSGPVDALASENSTMVGVGMCMEGIEHNPVVYELMSEMA FRSKKVQVQEWLKTYSRCRYGKADHYVDAAWNILYHTIYNCTDGIANHNTDFIVKLPDWDPSSTFDLKKPPHLWYSTQEVINALQLLVNVDDNLVHSATY RYDLVDLTRQVLGKLANEEYLKAVTAFRRQNVKAQNLHSKRFIQLIRDIDKLLASNSNFLLGTWLESAKKLATNPAEMKQYEWNARTQVTMWYDNTKVNQ SKLHDYANKYWSGLLEGYYLPRALTYFYYLSKSLRKNESFHLEDWRREWILFSNKWQAASELYPVKAEGNAVAISKALYEK |
Full Sequence |
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Protein Sequence Length: 775 Download |
MSNSHSSILL LILILLPLAL SQQEAIQAII HRLDSKALSP SIQEAAAKAL LRRLLPTHVD 60 SFEFQIVSRD VCGGGSCFLI SNFKSSSRNG AEILIRGTTA VEITSGLYWY LKYWCGAHVS 120 WDKTGGVQLA SIPKPGSLPF LKGNGVVIKR PVPWNYYQNV VTSSYSYVWW DWERWEKEID 180 WMALHGINLP LAFTGQESIW RNVFRDFNLA VKDLDNFFGG PAFLAWARMG NLHGWGGPLS 240 KNWLDQQLAL QKQILSRMRE LGMTPVLPSF SGNVPAGLVE IFPSANITKL GNWNSIDADP 300 STCCTYLLNP SDPLFVKIGE AFIRQQIKEY GDVTNIYSCD TFNENTPPTN DTSYISSLGA 360 SVYKAMVKAD KDAVWLMQGW LFYSDSDFWK PDQMKALLHS VPFGKMIVLD LFADVKPIWK 420 SSSQFYGTPY VWCMLHNFGG NIEMYGILDA ISSGPVDALA SENSTMVGVG MCMEGIEHNP 480 VVYELMSEMA FRSKKVQVQE WLKTYSRCRY GKADHYVDAA WNILYHTIYN CTDGIANHNT 540 DFIVKLPDWD PSSTFDLKKP PHLWYSTQEV INALQLLVNV DDNLVHSATY RYDLVDLTRQ 600 VLGKLANEEY LKAVTAFRRQ NVKAQNLHSK RFIQLIRDID KLLASNSNFL LGTWLESAKK 660 LATNPAEMKQ YEWNARTQVT MWYDNTKVNQ SKLHDYANKY WSGLLEGYYL PRALTYFYYL 720 SKSLRKNESF HLEDWRREWI LFSNKWQAAS ELYPVKAEGN AVAISKALYE KYFD* 780 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam12971 | NAGLU_N | 2.0e-17 | 56 | 141 | 86 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
pfam12972 | NAGLU_C | 5.0e-103 | 500 | 772 | 273 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
pfam05089 | NAGLU | 0 | 156 | 493 | 338 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI24942.1 | 0 | 6 | 774 | 67 | 868 | unnamed protein product [Vitis vinifera] |
GenBank | EEC75285.1 | 0 | 39 | 773 | 52 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
GenBank | EEE59081.1 | 0 | 39 | 773 | 52 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
RefSeq | XP_002273084.1 | 0 | 6 | 774 | 2 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002314048.1 | 0 | 18 | 773 | 21 | 805 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2vcc_A | 0 | 48 | 772 | 175 | 877 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
PDB | 2vcb_A | 0 | 48 | 772 | 175 | 877 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
PDB | 2vca_A | 0 | 48 | 772 | 175 | 877 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
PDB | 2vc9_A | 0 | 48 | 772 | 175 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
PDB | 4a4a_A | 0 | 48 | 772 | 198 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |