| Basic Information | |
|---|---|
| Species | Cucumis sativus |
| Cazyme ID | Cucsa.197210.1 |
| Family | GH89 |
| Protein Properties | Length: 788 Molecular Weight: 90362.6 Isoelectric Point: 6.0802 |
| Chromosome | Chromosome/Scaffold: 01357 Start: 682469 End: 691161 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH89 | 98 | 786 | 0 |
| PEILIAGVTGVEILAGLHWYLKHWCGAHISWDKTGGSQLFSVPKAGLLPRIQTNEVVVQRPIPLNYYQNAVTSSYSFAWWDWKRWEKEIDWMALQGINMP LAFTGQEAIWRKVFRKFNISNSDLDDFFGGPAFLAWSRMGNLHKWGGPLPQSWFDQQLILQKKVIGRMFELGMTPVLPAFSGNIPAAFKQIYPAAKITRL GNWFTVHSDPRWCCTYLLDAMDPLFVEIGKAFIEQQQKEYGRTSHVYNCDTFDENTPPVDDVEYISSLGSAIFGGMQAGDSNAVWLMQGWMFSYDPFWRP QQMKALLHSVPLGRLVVLDLYAEVKPIWISSEQFYGIPYIWKMYGILDSIASGPIEARSSPYSTMVGVGMSMEGIEQNPVVYDLMSEMAFQHNKVDVKKW LPQYSVRRYGHLVPSIQDAWDVLYHTVYNCTDGANDKNRDVIVAFPDVDPSAILVLPEGSNRHGNLDSSVDRLQDATFDRPHLWYPTSEVISALKLFIAG GDQLSSSNTYRYDLVDLTRQALAKYSNELFFRIVKAYQLHDVQTMASLSQEFLELVNDIDTLLACHEGFLLGPWLQSAKQLARSEEEEKQYEWNARTQIT MWFDNTEEEASLLRDYGNKYWSGLLGDYYCPRAAIYLKFLKESSENGYRFPLSNWRREWIKLTNDWQSSRKIYPVESNGDALDTSHWLY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 788 Download |
| MASFFSSTFL IFVTIFAAFS TSRSSTIGVE YISRLLEIQD RERVPAYVQV AAARGVLRRL 60 LPSHLPSFDF QIVSKDKCGG ESCFVIRNHR AFRKPGDPEI LIAGVTGVEI LAGLHWYLKH 120 WCGAHISWDK TGGSQLFSVP KAGLLPRIQT NEVVVQRPIP LNYYQNAVTS SYSFAWWDWK 180 RWEKEIDWMA LQGINMPLAF TGQEAIWRKV FRKFNISNSD LDDFFGGPAF LAWSRMGNLH 240 KWGGPLPQSW FDQQLILQKK VIGRMFELGM TPVLPAFSGN IPAAFKQIYP AAKITRLGNW 300 FTVHSDPRWC CTYLLDAMDP LFVEIGKAFI EQQQKEYGRT SHVYNCDTFD ENTPPVDDVE 360 YISSLGSAIF GGMQAGDSNA VWLMQGWMFS YDPFWRPQQM KALLHSVPLG RLVVLDLYAE 420 VKPIWISSEQ FYGIPYIWKM YGILDSIASG PIEARSSPYS TMVGVGMSME GIEQNPVVYD 480 LMSEMAFQHN KVDVKKWLPQ YSVRRYGHLV PSIQDAWDVL YHTVYNCTDG ANDKNRDVIV 540 AFPDVDPSAI LVLPEGSNRH GNLDSSVDRL QDATFDRPHL WYPTSEVISA LKLFIAGGDQ 600 LSSSNTYRYD LVDLTRQALA KYSNELFFRI VKAYQLHDVQ TMASLSQEFL ELVNDIDTLL 660 ACHEGFLLGP WLQSAKQLAR SEEEEKQYEW NARTQITMWF DNTEEEASLL RDYGNKYWSG 720 LLGDYYCPRA AIYLKFLKES SENGYRFPLS NWRREWIKLT NDWQSSRKIY PVESNGDALD 780 TSHWLYNX |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-21 | 49 | 136 | 88 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-92 | 496 | 787 | 292 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 6.0e-173 | 163 | 491 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 22 | 787 | 21 | 835 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 31 | 786 | 32 | 803 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 22 | 787 | 21 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 23 | 787 | 25 | 801 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 15 | 787 | 13 | 797 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 68 | 779 | 190 | 866 | A Chain A, Crystal Structure Of Highly Glycosylated Peroxidase From Royal Palm Tree |
| PDB | 2vcb_A | 0 | 68 | 779 | 190 | 866 | A Chain A, Crystal Structure Of Highly Glycosylated Peroxidase From Royal Palm Tree |
| PDB | 2vca_A | 0 | 68 | 779 | 190 | 866 | A Chain A, Crystal Structure Of Highly Glycosylated Peroxidase From Royal Palm Tree |
| PDB | 2vc9_A | 0 | 68 | 779 | 190 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 68 | 779 | 213 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
