| Basic Information | |
|---|---|
| Species | Cucumis sativus |
| Cazyme ID | Cucsa.252720.1 |
| Family | GH79 |
| Protein Properties | Length: 517 Molecular Weight: 57832.6 Isoelectric Point: 5.1438 |
| Chromosome | Chromosome/Scaffold: 02229 Start: 1590179 End: 1592558 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 16 | 510 | 0 |
| DENYICMTIDYWPFNECSTLPCLWDGNASALILVSIFIDLCCCCILFLVTLFFFYTKNLSLPTLTKAVQAFKTLRIRVGGSLQDKLVYDVGSFKGNCPQF ARNSSALFQISDGCLSMERWDDLNQFFNKTGAIVTFGLNALLGRHHTTGLQWEGDWNCTNAEAFIQYTIEKNYRINSWEFGNEMVGHNSIGANVTSAQYE KDLIKLREIIDRLYNNSQQKASIAAPSAFFYAPWYKDFVNGTGPGIVDILTHHIYNMGAGDDPKVINNFVDPNYLSKESKDFQQLKNIVENDAPWSVAWV GEAGGTFHGGSPYISNTFVDGFWYIDQLAMAALYNTKVYCRQTLVGGFYGILLPHTLAPSPDYYGALLFHRLMGSGVLKVDNNVSSYLRTYAHCSKERSG VTMLFINLSNETEFTVDIENNMMSTSLADKASQREEYHLIPNNGLVRSSTVLLNGNLLETTEDGDLPDLTPIYRDSNSSITIATWSIVFVVIPHF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 517 Download |
| MGKIVVDLTI RKAQTDENYI CMTIDYWPFN ECSTLPCLWD GNASALILVS IFIDLCCCCI 60 LFLVTLFFFY TKNLSLPTLT KAVQAFKTLR IRVGGSLQDK LVYDVGSFKG NCPQFARNSS 120 ALFQISDGCL SMERWDDLNQ FFNKTGAIVT FGLNALLGRH HTTGLQWEGD WNCTNAEAFI 180 QYTIEKNYRI NSWEFGNEMV GHNSIGANVT SAQYEKDLIK LREIIDRLYN NSQQKASIAA 240 PSAFFYAPWY KDFVNGTGPG IVDILTHHIY NMGAGDDPKV INNFVDPNYL SKESKDFQQL 300 KNIVENDAPW SVAWVGEAGG TFHGGSPYIS NTFVDGFWYI DQLAMAALYN TKVYCRQTLV 360 GGFYGILLPH TLAPSPDYYG ALLFHRLMGS GVLKVDNNVS SYLRTYAHCS KERSGVTMLF 420 INLSNETEFT VDIENNMMST SLADKASQRE EYHLIPNNGL VRSSTVLLNG NLLETTEDGD 480 LPDLTPIYRD SNSSITIATW SIVFVVIPHF EASACK* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 3.0e-135 | 2 | 343 | 342 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB08480.1 | 0 | 4 | 515 | 6 | 515 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CAB62595.1 | 0 | 4 | 515 | 10 | 520 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_196400.2 | 0 | 4 | 515 | 32 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | NP_200933.2 | 0 | 4 | 515 | 29 | 538 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
| RefSeq | XP_002514696.1 | 0 | 4 | 515 | 27 | 538 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00000002 | 129 | 431 | 115 | 408 | A Chain A, Structure Of Vigna Unguiculata Chitinase With Regulation Activity Of The Plant Cell Wall |
| PDB | 3vnz_A | 0.00000002 | 129 | 431 | 115 | 408 | A Chain A, Structure Of Vigna Unguiculata Chitinase With Regulation Activity Of The Plant Cell Wall |
| PDB | 3vny_A | 0.00000002 | 129 | 431 | 115 | 408 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
