Basic Information | |
---|---|
Species | Cucumis sativus |
Cazyme ID | Cucsa.359700.1 |
Family | AA3 |
Protein Properties | Length: 525 Molecular Weight: 57640.8 Isoelectric Point: 8.9012 |
Chromosome | Chromosome/Scaffold: 03588 Start: 539841 End: 541417 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
AA3 | 16 | 514 | 0 |
VDYYDYIIVGGGTAGCPLAATLSSKFRVLVLERGGVPHGNSNLMSQEGFLTTLMDDVHSRNSPVQAFTSEEGVPNARGRILGGSSAINAGFYSRADQAFF KNSQLKWDLAIVNQSYEWVEKEIVFKPNLKNWQSAVRDGMVEAGIIPYNGFSLDHVMGTKIGGSTFDELGRRHSAADLLSHATPFNIKVAIYANVERILL ASTVKRRPKAIGVLYRDQIGTYHHAMLHARGEVFLSAGAIGSPQLLLLSGIGSRPYLSSWGIPVAHHLPYVGHYLYDNPRNGISILAPMPLEQSLIQVAG ITESGTYLEAASNVIPFTSPPRSFFIRTPSPPVYLTVATLMEKITGPVASGSMRLASTDVRVNPVVRFNYFGNAVDLERCVNGTRKIGEILRSQAMEGFK FRDWFGRKEFRYVGPAYPEKEDEDGLVLREFCRQSVSTIWHYHGGCVAGKVVDSNYRVIGMEALRVVDGSIFGVSPGTNPQATVMMLGRHVGLQIINQR |
Full Sequence |
---|
Protein Sequence Length: 525 Download |
PDYLKFVSNA TEFPEVDYYD YIIVGGGTAG CPLAATLSSK FRVLVLERGG VPHGNSNLMS 60 QEGFLTTLMD DVHSRNSPVQ AFTSEEGVPN ARGRILGGSS AINAGFYSRA DQAFFKNSQL 120 KWDLAIVNQS YEWVEKEIVF KPNLKNWQSA VRDGMVEAGI IPYNGFSLDH VMGTKIGGST 180 FDELGRRHSA ADLLSHATPF NIKVAIYANV ERILLASTVK RRPKAIGVLY RDQIGTYHHA 240 MLHARGEVFL SAGAIGSPQL LLLSGIGSRP YLSSWGIPVA HHLPYVGHYL YDNPRNGISI 300 LAPMPLEQSL IQVAGITESG TYLEAASNVI PFTSPPRSFF IRTPSPPVYL TVATLMEKIT 360 GPVASGSMRL ASTDVRVNPV VRFNYFGNAV DLERCVNGTR KIGEILRSQA MEGFKFRDWF 420 GRKEFRYVGP AYPEKEDEDG LVLREFCRQS VSTIWHYHGG CVAGKVVDSN YRVIGMEALR 480 VVDGSIFGVS PGTNPQATVM MLGRHVGLQI INQRSAVTTH RVVY* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam05199 | GMC_oxred_C | 4.0e-28 | 362 | 503 | 147 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
TIGR01810 | betA | 4.0e-33 | 20 | 514 | 562 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
TIGR03970 | Rv0697 | 8.0e-40 | 20 | 503 | 524 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
COG2303 | BetA | 4.0e-46 | 19 | 510 | 554 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 0 | 19 | 514 | 538 | + Protein HOTHEAD |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABE65766.1 | 0 | 1 | 514 | 36 | 550 | mandelonitrile lyase [Arabidopsis thaliana] |
GenBank | ACN31582.1 | 0 | 3 | 514 | 37 | 582 | unknown [Zea mays] |
RefSeq | NP_177448.1 | 0 | 1 | 514 | 36 | 550 | (R)-mandelonitrile lyase, putative / (R)-oxynitrilase, putative [Arabidopsis thaliana] |
RefSeq | XP_002277531.1 | 0 | 1 | 514 | 32 | 546 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002311915.1 | 0 | 1 | 514 | 2 | 517 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3gdp_B | 0 | 3 | 516 | 11 | 519 | A Chain A, Crystal Structure Of Human Class I Alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue |
PDB | 3gdp_A | 0 | 3 | 516 | 11 | 519 | A Chain A, Crystal Structure Of Human Class I Alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue |
PDB | 3gdn_B | 0 | 3 | 516 | 11 | 519 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 3gdn_A | 0 | 3 | 516 | 11 | 519 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 1ju2_B | 0 | 3 | 516 | 11 | 519 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
EST Download unfiltered results here | ||||
---|---|---|---|---|
Hit | Length | Start | End | EValue |
HO796743 | 533 | 20 | 514 | 0 |
GO514057 | 227 | 234 | 460 | 0 |
FD579520 | 251 | 237 | 487 | 0 |
EX668479 | 219 | 1 | 219 | 0 |
FS465759 | 245 | 252 | 495 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
---|