| Basic Information | |
|---|---|
| Species | Eucalyptus grandis |
| Cazyme ID | Eucgr.B00338.1 |
| Family | GH89 |
| Protein Properties | Length: 823 Molecular Weight: 94124.2 Isoelectric Point: 5.9803 |
| Chromosome | Chromosome/Scaffold: 2 Start: 4742713 End: 4753023 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 104 | 810 | 0 |
| PEILISGVTGVEVLAGLHWYLKYWCGSHISWDKTGGLQTYSMPKFGSLPRVHDAGVIVQRPIPWSYYQNAVSSSYSFAWWDWKRWEKEIDWMALQGINLP LAFTGQEAIWQKVFQQKFNISTSNLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWLDQQLRLQKKILERMYELGMTPVLPAFSGNVPAALKDIFPSAKITR LGNWFSVESNPRWCCTYLLDATDPLFVEIGRAFIEQQLREYGRTGHIYNCDTFDENTPPIDEPAYISSLGAAIFEGMQSGDADAVWLMQGWLFSYDPFWR PPQMKALLHSVPLGKLVVLDLFAEVKPIWMTSEQFYGVPYIWKVSFLCMLHNFAGNIEMYGVLDAVASGPIEAYMSENSTMVGVGMSMEGIEQNPVVYDL MSEMAFQQRKVDVKTWIDLYSTRRYGQSVSSIKEAWNILHHTIYNCTDGLYDKNRDVIVAFPDADPSSISFSQLRYHRYGKPLFRGAVLNEKTGLTDEPH MWYSTSEVVRALELFLAGGDQLQSSDTYRYDLVDLTRQALAKFANELFLKVIEDYQRQDAYGVAFHSQKFLNLVEDMDTLLACHEGFLLGPWLESAKQLA QNKEQERQFEWNARTQITMWFDNSVEEASLLRDYGNKYWSGLLRDYYGPRAALYFKFLKESLAEGHDFRLKEWRREWVKLTNDWQNSRNLFPTQSVGHAF HTSQWLY | |||
| Full Sequence |
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| Protein Sequence Length: 823 Download |
| MARPPLPAAA PLAFLLLVLV LSAVAPAARC STAGVGYVSR LLEIQDRERA PATVQLAAAR 60 GALRRLLPSR YSSFEFRIIS KDECGGEICF VITNHPSFGR RGAPEILISG VTGVEVLAGL 120 HWYLKYWCGS HISWDKTGGL QTYSMPKFGS LPRVHDAGVI VQRPIPWSYY QNAVSSSYSF 180 AWWDWKRWEK EIDWMALQGI NLPLAFTGQE AIWQKVFQQK FNISTSNLDD FFGGPAFLAW 240 SRMGNLHGWG GPLPQSWLDQ QLRLQKKILE RMYELGMTPV LPAFSGNVPA ALKDIFPSAK 300 ITRLGNWFSV ESNPRWCCTY LLDATDPLFV EIGRAFIEQQ LREYGRTGHI YNCDTFDENT 360 PPIDEPAYIS SLGAAIFEGM QSGDADAVWL MQGWLFSYDP FWRPPQMKAL LHSVPLGKLV 420 VLDLFAEVKP IWMTSEQFYG VPYIWKVSFL CMLHNFAGNI EMYGVLDAVA SGPIEAYMSE 480 NSTMVGVGMS MEGIEQNPVV YDLMSEMAFQ QRKVDVKTWI DLYSTRRYGQ SVSSIKEAWN 540 ILHHTIYNCT DGLYDKNRDV IVAFPDADPS SISFSQLRYH RYGKPLFRGA VLNEKTGLTD 600 EPHMWYSTSE VVRALELFLA GGDQLQSSDT YRYDLVDLTR QALAKFANEL FLKVIEDYQR 660 QDAYGVAFHS QKFLNLVEDM DTLLACHEGF LLGPWLESAK QLAQNKEQER QFEWNARTQI 720 TMWFDNSVEE ASLLRDYGNK YWSGLLRDYY GPRAALYFKF LKESLAEGHD FRLKEWRREW 780 VKLTNDWQNS RNLFPTQSVG HAFHTSQWLY DKYLRDPDTY DQ* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 8.0e-15 | 68 | 154 | 87 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 7.0e-92 | 518 | 813 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 169 | 510 | 342 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 9 | 821 | 2 | 845 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 30 | 818 | 18 | 811 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 9 | 821 | 2 | 812 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 29 | 822 | 25 | 812 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 18 | 822 | 10 | 809 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 56 | 798 | 171 | 861 | A Chain A, Crystal Structure Of Galactose Oxidase, W290h Mutant |
| PDB | 2vcb_A | 0 | 56 | 798 | 171 | 861 | A Chain A, Crystal Structure Of Galactose Oxidase, W290h Mutant |
| PDB | 2vca_A | 0 | 56 | 798 | 171 | 861 | A Chain A, Crystal Structure Of Galactose Oxidase, W290h Mutant |
| PDB | 2vc9_A | 0 | 56 | 798 | 171 | 861 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 56 | 798 | 194 | 884 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
