| Basic Information | |
|---|---|
| Species | Eucalyptus grandis |
| Cazyme ID | Eucgr.B00338.2 |
| Family | GH89 |
| Protein Properties | Length: 733 Molecular Weight: 82800.8 Isoelectric Point: 5.9218 |
| Chromosome | Chromosome/Scaffold: 2 Start: 4742713 End: 4753023 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 104 | 712 | 0 |
| PEILISGVTGVEVLAGLHWYLKYWCGSHISWDKTGGLQTYSMPKFGSLPRVHDAGVIVQRPIPWSYYQNAVSSSYSFAWWDWKRWEKEIDWMALQGINLP LAFTGQEAIWQKVFQKFNISTSNLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWLDQQLRLQKKILERMYELGMTPVLPAFSGNVPAALKDIFPSAKITRL GNWFSVESNPRWCCTYLLDATDPLFVEIGRAFIEQQLREYGRTGHIYNCDTFDENTPPIDEPAYISSLGAAIFEGMQSGDADAVWLMQGWLFSYDPFWRP PQMKALLHSVPLGKLVVLDLFAEVKPIWMTSEQFYGVPYIWKVSFLCMLHNFAGNIEMYGVLDAVASGPIEAYMSENSTMVGVGMSMEGIEQNPVVYDLM SEMAFQQRKVDVKTWIDLYSTRRYGQSVSSIKEAWNILHHTIYNCTDGLYDKNRDVIVAFPDADPSSISFSQLRYHRYGKPLFRGAVLNEKTGLTDEPHM WYSTSEVVRALELFLAGGDQLQSSDTYRYDLVDLTRQALAKFANELFLKVIEDYQRQDAYGVAFHSQKFLNLVEDMDTLLACHEGFLLGPWLESAKQLAQ NKEQERQVQ | |||
| Full Sequence |
|---|
| Protein Sequence Length: 733 Download |
| MARPPLPAAA PLAFLLLVLV LSAVAPAARC STAGVGYVSR LLEIQDRERA PATVQLAAAR 60 GALRRLLPSR YSSFEFRIIS KDECGGEICF VITNHPSFGR RGAPEILISG VTGVEVLAGL 120 HWYLKYWCGS HISWDKTGGL QTYSMPKFGS LPRVHDAGVI VQRPIPWSYY QNAVSSSYSF 180 AWWDWKRWEK EIDWMALQGI NLPLAFTGQE AIWQKVFQKF NISTSNLDDF FGGPAFLAWS 240 RMGNLHGWGG PLPQSWLDQQ LRLQKKILER MYELGMTPVL PAFSGNVPAA LKDIFPSAKI 300 TRLGNWFSVE SNPRWCCTYL LDATDPLFVE IGRAFIEQQL REYGRTGHIY NCDTFDENTP 360 PIDEPAYISS LGAAIFEGMQ SGDADAVWLM QGWLFSYDPF WRPPQMKALL HSVPLGKLVV 420 LDLFAEVKPI WMTSEQFYGV PYIWKVSFLC MLHNFAGNIE MYGVLDAVAS GPIEAYMSEN 480 STMVGVGMSM EGIEQNPVVY DLMSEMAFQQ RKVDVKTWID LYSTRRYGQS VSSIKEAWNI 540 LHHTIYNCTD GLYDKNRDVI VAFPDADPSS ISFSQLRYHR YGKPLFRGAV LNEKTGLTDE 600 PHMWYSTSEV VRALELFLAG GDQLQSSDTY RYDLVDLTRQ ALAKFANELF LKVIEDYQRQ 660 DAYGVAFHSQ KFLNLVEDMD TLLACHEGFL LGPWLESAKQ LAQNKEQERQ VQRLSVTDLL 720 VKELFGNLTS AK* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam12971 | NAGLU_N | 5.0e-15 | 68 | 154 | 87 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
| pfam12972 | NAGLU_C | 5.0e-54 | 517 | 710 | 194 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam05089 | NAGLU | 0 | 169 | 509 | 341 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 9 | 712 | 2 | 737 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 30 | 712 | 18 | 706 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 9 | 712 | 2 | 704 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 29 | 712 | 25 | 703 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 18 | 712 | 10 | 699 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 56 | 706 | 171 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 56 | 706 | 171 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 56 | 706 | 171 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 56 | 706 | 171 | 768 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 74 | 706 | 213 | 791 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
