Basic Information | |
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Species | Eucalyptus grandis |
Cazyme ID | Eucgr.G02460.1 |
Family | GH79 |
Protein Properties | Length: 522 Molecular Weight: 57528.4 Isoelectric Point: 5.8498 |
Chromosome | Chromosome/Scaffold: 7 Start: 43172390 End: 43175169 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 39 | 515 | 0 |
DDNFVCATLDWWPVDKCDYGQCPWGMAGIINLDLKNKILSNAIKAFNPLRIRVGGSLQDQVIYKVGDARPVHKCPHFKKQPSGMFGFSRGCLTMDRWDQL NELFNETGAALTFGLNALIGRHRSPNDSDHFIGDWDSQNARDLMSYTISKGYKMDSYELGNELCGSGVSGRVDADQYGKDMIVLKKMIEELYPDPATRPK VLGPAGFYDQKWFETFLQASGPNVVDGLTHHIYNLGAGVDPTLIDKIQDPYFLDEIAQTHKDVMRTAERFGPWSGPWVGEAGGAYNSGGKDVSHTFANGF WYLDQLGMTSQFNHKVFCRQALIGGNYGLLNTTSFVPNPDYYGALLWHRLMGKHVLATMHDGSAHLRAYSHCSKDKPGVSLILINMSNSTSFNVSVVNDL NIYPAVEQACGGRQPREEYHLTPKDGNIQSDVLLLNGTPLELTELSDIPEMKPELVDPSLPIAVAADSIVYATLRDF |
Full Sequence |
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Protein Sequence Length: 522 Download |
MAEFKAICCF AAVLSWLSLC LAKDVTVTVA GVTDVARTDD NFVCATLDWW PVDKCDYGQC 60 PWGMAGIINL DLKNKILSNA IKAFNPLRIR VGGSLQDQVI YKVGDARPVH KCPHFKKQPS 120 GMFGFSRGCL TMDRWDQLNE LFNETGAALT FGLNALIGRH RSPNDSDHFI GDWDSQNARD 180 LMSYTISKGY KMDSYELGNE LCGSGVSGRV DADQYGKDMI VLKKMIEELY PDPATRPKVL 240 GPAGFYDQKW FETFLQASGP NVVDGLTHHI YNLGAGVDPT LIDKIQDPYF LDEIAQTHKD 300 VMRTAERFGP WSGPWVGEAG GAYNSGGKDV SHTFANGFWY LDQLGMTSQF NHKVFCRQAL 360 IGGNYGLLNT TSFVPNPDYY GALLWHRLMG KHVLATMHDG SAHLRAYSHC SKDKPGVSLI 420 LINMSNSTSF NVSVVNDLNI YPAVEQACGG RQPREEYHLT PKDGNIQSDV LLLNGTPLEL 480 TELSDIPEMK PELVDPSLPI AVAADSIVYA TLRDFRAPAC A* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 41 | 345 | 305 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 15 | 520 | 17 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 15 | 520 | 15 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 6 | 521 | 7 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 22 | 519 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00000000000004 | 27 | 100 | 510 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00000002 | 89 | 435 | 75 | 411 | A Chain A, Crystal Structure Of A Rice Os3bglu6 Beta-glucosidase |
PDB | 3vnz_A | 0.00000002 | 89 | 435 | 75 | 411 | A Chain A, Crystal Structure Of A Rice Os3bglu6 Beta-glucosidase |
PDB | 3vny_A | 0.00000002 | 89 | 435 | 75 | 411 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |