| Basic Information | |
|---|---|
| Species | Eucalyptus grandis |
| Cazyme ID | Eucgr.G03358.2 |
| Family | GH89 |
| Protein Properties | Length: 697 Molecular Weight: 79074.8 Isoelectric Point: 6.7102 |
| Chromosome | Chromosome/Scaffold: 7 Start: 51651699 End: 51661005 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 72 | 665 | 0 |
| IPKAGSLPRLKGKGVMIQRPVPWNYYQNVVTSSYSYVWWNWSGWEKEIDWMALQGVNLPLAFTGQEAIWQKVFMDFNISKDELNDFFGGPAFLAWARMGN LHGWGGPLSQNWLDQQLNLQKQILSRMSELGMVPVLPSFSGNVPEALKKIHPSANITRLGDWNTVDGNPKWCCTYLLDPSDPLFVEIGEAFVRKQIKEYG DVTDIYNCDTFNENSPPSNDTTYISMLGAAVYRAMSQGDKDAVWLMQGWLFYSDSAFWKPPQMKALLHSVPVGKMIVLDLFADVKPIWETSAQFYGTPYV WCLLHNFGGNIEMYGVLDAISSGPVDARISDNSTMVGVGMCMEGIEHNPVVYELMSEMAFRSEKVLVAEWLKAYSRRRYGKTVRQVEAAWEILYHTIYNC TDGIADHNTDFIVKFPDWDPSTISASSFGKQEKMLLPFHLSPGRRFLSQATGSDFPQAHLWYSTRFVVDALELFLQAGNHLKESLPFRYDLVDLTRQVLS KLANKVYVDAMTAFQQKDAKALHLHSQKFLQLIKDIDLLLACDDNFLLGTWLESAKALAATPSEMRQYEWNARTQVTMWYDTNRTAQSKLHDYG | |||
| Full Sequence |
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| Protein Sequence Length: 697 Download |
| MKISALVLLL SVITMTSSAS SPDVIESLLT RLESKRASPS VQETAAAGVL ERLLPFHSRS 60 FQFKIVPKVA SIPKAGSLPR LKGKGVMIQR PVPWNYYQNV VTSSYSYVWW NWSGWEKEID 120 WMALQGVNLP LAFTGQEAIW QKVFMDFNIS KDELNDFFGG PAFLAWARMG NLHGWGGPLS 180 QNWLDQQLNL QKQILSRMSE LGMVPVLPSF SGNVPEALKK IHPSANITRL GDWNTVDGNP 240 KWCCTYLLDP SDPLFVEIGE AFVRKQIKEY GDVTDIYNCD TFNENSPPSN DTTYISMLGA 300 AVYRAMSQGD KDAVWLMQGW LFYSDSAFWK PPQMKALLHS VPVGKMIVLD LFADVKPIWE 360 TSAQFYGTPY VWCLLHNFGG NIEMYGVLDA ISSGPVDARI SDNSTMVGVG MCMEGIEHNP 420 VVYELMSEMA FRSEKVLVAE WLKAYSRRRY GKTVRQVEAA WEILYHTIYN CTDGIADHNT 480 DFIVKFPDWD PSTISASSFG KQEKMLLPFH LSPGRRFLSQ ATGSDFPQAH LWYSTRFVVD 540 ALELFLQAGN HLKESLPFRY DLVDLTRQVL SKLANKVYVD AMTAFQQKDA KALHLHSQKF 600 LQLIKDIDLL LACDDNFLLG TWLESAKALA ATPSEMRQYE WNARTQVTMW YDTNRTAQSK 660 LHDYGTSCTC FCPYTCMRVY IYLHACVYRH FWICVP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 0.002 | 42 | 68 | 27 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-73 | 440 | 664 | 225 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 96 | 435 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0.000000002 | 7 | 68 | 73 | 134 | unnamed protein product [Vitis vinifera] |
| EMBL | CBI24942.1 | 0 | 68 | 666 | 193 | 792 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002273084.1 | 0 | 68 | 666 | 128 | 727 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0.0000002 | 20 | 68 | 24 | 72 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002314048.1 | 0 | 68 | 666 | 132 | 730 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 83 | 664 | 258 | 800 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 83 | 664 | 258 | 800 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 83 | 664 | 258 | 800 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 83 | 664 | 258 | 800 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 83 | 664 | 281 | 823 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
