| Basic Information | |
|---|---|
| Species | Eucalyptus grandis |
| Cazyme ID | Eucgr.K01959.1 |
| Family | GH31 |
| Protein Properties | Length: 271 Molecular Weight: 30180.9 Isoelectric Point: 9.3482 |
| Chromosome | Chromosome/Scaffold: 11 Start: 25097751 End: 25098739 |
| Description | Glycosyl hydrolases family 31 protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH31 | 1 | 110 | 1.3004e-42 |
| MQLGAFYPFARDHSVKNSIRRELYLWDSVATSARKVLGLRYRLLPYLYTLMYEAYRKGIPIAQPLFFSFPEDKMTYHINSQFLIGKGVMVTPILQSGANT VDAYIPSGNW | |||
| Full Sequence |
|---|
| Protein Sequence Length: 271 Download |
| MQLGAFYPFA RDHSVKNSIR RELYLWDSVA TSARKVLGLR YRLLPYLYTL MYEAYRKGIP 60 IAQPLFFSFP EDKMTYHINS QFLIGKGVMV TPILQSGANT VDAYIPSGNW EGNILAMQGE 120 AMTTKVARRT PFELLVVVDE NGNSSGQVFL DDGEDVEMGG EGNKWTLVKF YCEKTGNGVV 180 VRSEVVNGEF ALIEKWVIDK VTILGLRKGT RMMKLRGHEL YNEVEAKSGQ RTMTIAGKLS 240 GGGEFVIAEV SGLSLLLGKT FKLEVKLRQS * 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK10658 | PRK10658 | 1.0e-7 | 53 | 110 | 58 | + putative alpha-glucosidase; Provisional | ||
| PRK10426 | PRK10426 | 4.0e-12 | 53 | 110 | 58 | + alpha-glucosidase; Provisional | ||
| COG1501 | COG1501 | 2.0e-17 | 1 | 145 | 175 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
| cd06602 | GH31_MGAM_SI_GAA | 3.0e-21 | 1 | 76 | 77 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
| pfam01055 | Glyco_hydro_31 | 5.0e-34 | 1 | 110 | 111 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN60336.1 | 0 | 1 | 267 | 594 | 890 | hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002317678.1 | 0 | 1 | 267 | 619 | 912 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002317679.1 | 0 | 1 | 267 | 611 | 904 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002333838.1 | 0 | 1 | 267 | 602 | 895 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002534242.1 | 0 | 1 | 269 | 616 | 914 | alpha-glucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3w38_A | 0 | 1 | 267 | 614 | 908 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
| PDB | 3w37_A | 0 | 1 | 267 | 614 | 908 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
| PDB | 3top_B | 1e-31 | 1 | 206 | 621 | 861 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
| PDB | 3top_A | 1e-31 | 1 | 206 | 621 | 861 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
| PDB | 3ton_B | 1e-31 | 1 | 206 | 621 | 861 | A Chain A, Crystral Structure Of The C-Terminal Subunit Of Human Maltase- Glucoamylase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| DR918111 | 292 | 5 | 264 | 0 |
| DT551076 | 238 | 1 | 206 | 0 |
| EY819184 | 283 | 13 | 263 | 0 |
| ES796379 | 291 | 17 | 271 | 0 |
| EY661628 | 252 | 1 | 220 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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