Basic Information | |
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Species | Eucalyptus grandis |
Cazyme ID | Eucgr.K02497.1 |
Family | GH79 |
Protein Properties | Length: 541 Molecular Weight: 60001.3 Isoelectric Point: 8.5486 |
Chromosome | Chromosome/Scaffold: 11 Start: 32204768 End: 32209321 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 40 | 534 | 0 |
DDNFICATLDWWPHDKCNYNMCPWGYTSVINLNLSHPVLGNAIQAFKRLRIRIGGSLQDQVLYDIGKLKYPCHPFGKEKGGLFGFSTGCLRMNRWDELNH LFSRTGALVTFGLNALYGRHQIKKGVWGGDWDFSNAYELINYTSAKKYPIDAWEFGNELSGSGIGASVGVEQYGKDLVSLKAIVSEVYKNARSKPSLVAP GGFFDQDWYRKLLQVSGSGVINAMTHHIYNLGPGSDPNLVSKILNPNYLSQISKTFSNVRQTIQENGPWASPWVGESGGAYNSGGQHVSDTFVNSFWYLD QLGMASKYGTKVYCRQTLIGGNYGLLDTSTFEPNPDYYSALLWHQLMGKGVLAIDSDASSFLRYYAHCSKGREGITLLLINFSNITSFSISVRNSKNYRL HIERSISKESIFIRRLKETGSFVGLGSSDGQLFREEYHLTPKDGVLQSKITLLNGTPLELTKDREIPDLKPARVDVDTPLTIAPLSIKFVVFPNF |
Full Sequence |
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Protein Sequence Length: 541 Download |
MGVFCLSLFV LLSYLSPGFA QKVAYSKLIV DGSNTVAQTD DNFICATLDW WPHDKCNYNM 60 CPWGYTSVIN LNLSHPVLGN AIQAFKRLRI RIGGSLQDQV LYDIGKLKYP CHPFGKEKGG 120 LFGFSTGCLR MNRWDELNHL FSRTGALVTF GLNALYGRHQ IKKGVWGGDW DFSNAYELIN 180 YTSAKKYPID AWEFGNELSG SGIGASVGVE QYGKDLVSLK AIVSEVYKNA RSKPSLVAPG 240 GFFDQDWYRK LLQVSGSGVI NAMTHHIYNL GPGSDPNLVS KILNPNYLSQ ISKTFSNVRQ 300 TIQENGPWAS PWVGESGGAY NSGGQHVSDT FVNSFWYLDQ LGMASKYGTK VYCRQTLIGG 360 NYGLLDTSTF EPNPDYYSAL LWHQLMGKGV LAIDSDASSF LRYYAHCSKG REGITLLLIN 420 FSNITSFSIS VRNSKNYRLH IERSISKESI FIRRLKETGS FVGLGSSDGQ LFREEYHLTP 480 KDGVLQSKIT LLNGTPLELT KDREIPDLKP ARVDVDTPLT IAPLSIKFVV FPNFDAPVCA 540 * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 27 | 342 | 316 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 17 | 540 | 15 | 513 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_200933.2 | 0 | 3 | 540 | 6 | 539 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 17 | 540 | 15 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321464.1 | 0 | 4 | 540 | 3 | 541 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514696.1 | 0 | 19 | 540 | 18 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00006 | 260 | 430 | 235 | 409 | A Chain A, Crystal Structure Of Erv41p |
PDB | 3vnz_A | 0.00006 | 260 | 430 | 235 | 409 | A Chain A, Crystal Structure Of Erv41p |
PDB | 3vny_A | 0.00006 | 260 | 430 | 235 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |