Basic Information | |
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Species | Zea mays |
Cazyme ID | GRMZM2G025048_T01 |
Family | GT31 |
Protein Properties | Length: 626 Molecular Weight: 68621.4 Isoelectric Point: 6.8295 |
Chromosome | Chromosome/Scaffold: 1 Start: 267898328 End: 267901524 |
Description | Galactosyltransferase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT31 | 425 | 495 | 1.9e-22 |
ERMGVRKTWMSVVHKSPNMVARFFVALHGRTEVNAELKKEAEFFRDIVFVPFLDNYDLVVMKTLAICEYGL |
Full Sequence |
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Protein Sequence Length: 626 Download |
MRKAASTATA GAGATFRRRA MEGLATVLLL YALLVLALES PLVSTSPFGG AAGGTARKLH 60 LSFGAGERAA PARPASASVP GASAHGQDHR LSRFATGLDV RLLDSARSGA LRRSIADAVA 120 AGARAFSDLE ALDPAVVAAP SGESDAARCP HSIALTAEEL GARGRVVELP CGLALGSHIT 180 VAATPRAPHE ERNPAIVVLR DGERHAMVSQ FMVELQGLRA VDGEDPPRVL HFNPRLRGDW 240 SGHPVIERNT CYRMSWGAVQ RCDGWRSRPD EETVDGLVKC EKWIRDDDDR LEKSKTTSKT 300 AWWLNRLIGQ KEEVNFGWPF PFVEGRLFVL TLSAGLEGYH VSVDGRHVTS FPYRTGFVLE 360 DATGLSLNGD LDVHSVIAGS LPTTHPSFVP QNYLEFSTVW QAPLLPDEPV EIFIGILSAA 420 NHFAERMGVR KTWMSVVHKS PNMVARFFVA LHGRTEVNAE LKKEAEFFRD IVFVPFLDNY 480 DLVVMKTLAI CEYGLANFGL ARVFGIPVRT FTHEVVTLWY RAPEILLGER QYSMPVDVWV 540 LGTPNEQSWP GVTSLPDFKS AFPKCQSQDL AAVVPNLEPA GLDLLSPIYV FIAHGQKMLR 600 YEPSKRITAR QALEHDYFKD LEMVQ* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd07860 | STKc_CDK2_3 | 3.0e-50 | 495 | 618 | 154 | + Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3. Serine/Threonine Kinases (STKs), Cyclin-dependent protein kinase 2 (CDK2) and CDK3 subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. | ||
cd07829 | STKc_CDK_like | 4.0e-57 | 495 | 618 | 154 | + Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase (CDK)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. | ||
cd07835 | STKc_CDK1_like | 4.0e-62 | 495 | 618 | 154 | + Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 1 (CDK1)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. This subfamily is composed of CDK1 from higher eukaryotes, plants, and yeasts, as well as CDK2 and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. | ||
PLN00009 | PLN00009 | 8.0e-65 | 495 | 625 | 161 | + cyclin-dependent kinase A; Provisional | ||
PLN03133 | PLN03133 | 5.0e-67 | 148 | 494 | 357 | + beta-1,3-galactosyltransferase; Provisional |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005524 | ATP binding |
GO:0005529 | Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] |
GO:0006468 | protein phosphorylation |
GO:0006486 | protein glycosylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAS07235.1 | 0 | 12 | 495 | 7 | 494 | putative galactosyltransferase, 3'-partial [Oryza sativa Japonica Group] |
GenBank | EAY92235.1 | 0 | 12 | 495 | 7 | 494 | hypothetical protein OsI_13955 [Oryza sativa Indica Group] |
GenBank | EAZ03101.1 | 0 | 64 | 495 | 67 | 514 | hypothetical protein OsI_25245 [Oryza sativa Indica Group] |
RefSeq | NP_001059116.1 | 0 | 64 | 495 | 69 | 502 | Os07g0195200 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002463707.1 | 0 | 9 | 495 | 4 | 495 | hypothetical protein SORBIDRAFT_01g004630 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2jgz_A | 6e-37 | 495 | 620 | 144 | 289 | A Chain A, Crystal Structure Of Phospho-Cdk2 In Complex With Cyclin B |
PDB | 1pkd_C | 8e-37 | 495 | 621 | 144 | 290 | A Chain A, Crystal Structure Of Phospho-Cdk2 In Complex With Cyclin B |
PDB | 1pkd_A | 8e-37 | 495 | 621 | 144 | 290 | A Chain A, Crystal Structure Of Phospho-Cdk2 In Complex With Cyclin B |
PDB | 1e9h_C | 8e-37 | 495 | 621 | 144 | 290 | B Chain B, Thr 160 Phosphorylated Cdk2-Human Cyclin A3 Complex With The Inhibitor Indirubin-5-Sulphonate Bound |
PDB | 1e9h_A | 8e-37 | 495 | 621 | 144 | 290 | B Chain B, Thr 160 Phosphorylated Cdk2-Human Cyclin A3 Complex With The Inhibitor Indirubin-5-Sulphonate Bound |