y
Basic Information | |
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Species | Zea mays |
Cazyme ID | GRMZM2G026855_T05 |
Family | GH28 |
Protein Properties | Length: 623 Molecular Weight: 66667.3 Isoelectric Point: 8.1344 |
Chromosome | Chromosome/Scaffold: 3 Start: 169071206 End: 169080562 |
Description | Zinc-binding dehydrogenase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH28 | 55 | 247 | 0 |
DACRSPLPAAVYVPPGRYLVRSATFTGPCHTRAVTFAVAGTVVAPAAYGARGSSGRWITFENMDGLVVAGGGTLDGRGRALWACRQRGQRDCPTPTSTLT IANSKDVVVAGLRSVDSELFHVVVLQCHGVTVRGVTVEAPADSPNTDGIHLHMSTHVSVYDARISTGDDCISIGPGNSHLWIERVACGPGHGI |
Full Sequence |
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Protein Sequence Length: 623 Download |
MAMPKPVLSL LVHLHAAVLF LPAPAGGAVY NVLRYGARPD GVTDAAGPFL RAWADACRSP 60 LPAAVYVPPG RYLVRSATFT GPCHTRAVTF AVAGTVVAPA AYGARGSSGR WITFENMDGL 120 VVAGGGTLDG RGRALWACRQ RGQRDCPTPT STLTIANSKD VVVAGLRSVD SELFHVVVLQ 180 CHGVTVRGVT VEAPADSPNT DGIHLHMSTH VSVYDARIST GDDCISIGPG NSHLWIERVA 240 CGPGHGIRKV PAEELGGRKA KPTCSRAGGD SGMERERQAV ARNRKVVLRG YIDRAPREED 300 MELVDGGAVE LRVPEGGGGP AVLVKNLYLS CDPYMRGRMR DFRNSYIPPF KPGSPIEGFG 360 VGRVVDSTHP GFSAGDVVSG MTGWEDYSLI TKPEQLRKIQ QSDIPLSYHL GLLGMPGFTA 420 YVGFYEICSP KKGEFVFVSA ASGAVGQIVG QLAKLHGCYV VGSAGTDQKV ELLKEKFGFD 480 AAFNYKEEPD LTAALKRHFP EGIDIYFENV GGPMLDAVLL NMRVHGRIAV CGMVSQHGVT 540 APAGIHNLFS LISKRIEMKG FIQSDYVHLF PQFVDDITRH YRDGKIVYVE DMSVGLESGP 600 ASFVGLFSGK NVGKQVVCVS RD* 660 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd08294 | leukotriene_B4_DH_like | 1.0e-101 | 282 | 617 | 342 | + 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto- 13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. | ||
COG2130 | COG2130 | 6.0e-127 | 282 | 620 | 341 | + Putative NADP-dependent oxidoreductases [General function prediction only] | ||
cd05288 | PGDH | 2.0e-157 | 283 | 617 | 336 | + Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. | ||
PLN03154 | PLN03154 | 0 | 276 | 622 | 349 | + putative allyl alcohol dehydrogenase; Provisional | ||
cd08295 | double_bond_reductase_like | 0 | 281 | 619 | 340 | + Arabidopsis alkenal double bond reductase and leukotriene B4 12-hydroxydehydrogenase. This group includes proteins identified as the Arabidopsis alkenal double bond reductase and leukotriene B4 12-hydroxydehydrogenase. The Arabidopsis enzyme, a member of the medium chain dehydrogenase/reductase family, catalyzes the reduction of 7-8-double bond of phenylpropanal substrates as a plant defense mechanism. Prostaglandins and related eicosanoids (lipid mediators involved in host defense and inflamation) are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. Leukotriene B4 (LTB4) can be metabolized by LTB4 20-hydroxylase in inflamatory cells, and in other cells by bifunctional LTB4 12-HD/PGR. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. |
Gene Ontology | |
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GO Term | Description |
GO:0004650 | polygalacturonase activity |
GO:0005975 | carbohydrate metabolic process |
GO:0008270 | zinc ion binding |
GO:0016491 | oxidoreductase activity |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACF85153.1 | 0 | 273 | 622 | 1 | 350 | unknown [Zea mays] |
GenBank | ACN28438.1 | 0 | 117 | 622 | 1 | 506 | unknown [Zea mays] |
RefSeq | NP_001045054.1 | 0 | 273 | 622 | 1 | 353 | Os01g0891300 [Oryza sativa (japonica cultivar-group)] |
RefSeq | NP_001149563.1 | 0 | 273 | 622 | 1 | 350 | LOC100283189 [Zea mays] |
RefSeq | XP_002456768.1 | 0 | 273 | 622 | 1 | 351 | hypothetical protein SORBIDRAFT_03g042360 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 4hfn_B | 0 | 283 | 622 | 7 | 343 | A Chain A, T. Thermophilus 16s Rrna N2 G1207 Methyltransferase (Rsmc) In Complex With Adomet |
PDB | 4hfn_A | 0 | 283 | 622 | 7 | 343 | A Chain A, T. Thermophilus 16s Rrna N2 G1207 Methyltransferase (Rsmc) In Complex With Adomet |
PDB | 4hfm_B | 0 | 283 | 622 | 7 | 343 | A Chain A, T. Thermophilus 16s Rrna N2 G1207 Methyltransferase (Rsmc) In Complex With Adomet |
PDB | 4hfm_A | 0 | 283 | 622 | 7 | 343 | A Chain A, T. Thermophilus 16s Rrna N2 G1207 Methyltransferase (Rsmc) In Complex With Adomet |
PDB | 4hfj_B | 0 | 283 | 622 | 7 | 343 | A Chain A, X-ray Crystal Structure Of A Double Bond Reductase From Nicotiana Tabacum |