| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G033592_T01 |
| Family | GH89 |
| Protein Properties | Length: 815 Molecular Weight: 92201.1 Isoelectric Point: 7.7177 |
| Chromosome | Chromosome/Scaffold: 9 Start: 128538802 End: 128548820 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 106 | 810 | 0 |
| AEILIQGTTAVELASGLHWYLKYWCGAHISWDKTGGAQLASIPSPGSLPRVQGKGVKIERPVPWNYYQNVVTSSYSFVWWDWKRWEKEIDWMALQGINLP LAFTGQESIWQKVFKSFNVTDRDLDDFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLALQKKILSRMIELGMVPVLPSFSGNVPAIFAKLFPSANITRL GDWNTVDANPKWCCTYLLDPSDSLFIDVGQAFIRQQIKEYGDVTNIYNCDTFNENTPPTDEPAYISSLGSAIYEAMSRGNKNAVWLMQGWLFYSDAAFWK EPQMKALLHSVPIGKMIVLDLFADVKPIWKVSSQFYGVPYIWCMLHNFGGNIEMYGILDSISSGPIDARTSYNSTMIGVGMCMEGIEHNPVVYELMSEMA FHNKKVEVEDWLKTYSCRRYGQANADIEKAWRYLYHTIYNCTDGIADHNKDYIVEFPDISPSSVTYQVSKRRGMSITRNHRRFFLSEVSGILPQPHLWYS TKEAVKALELFLDAGSTFSESLTYRYDLVDLTRQCLSKLANEVYLDAISLYQKKDSHGLNAHARKFLEIIVDIDTLLAADDNFLLGPWLESAKSLAITEK ERQQYEWNARTQVTMWYDNTETEQSKLHDYANKFWSGLLKSYYLPRASKYFAYLTRSLQENRSFQLEEWRKDWISYSNEWQSGKEVYAVKATGDALAIAR SLYRK | |||
| Full Sequence |
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| Protein Sequence Length: 815 Download |
| MMRPSPPRRL SLAAPFLILL LLTLLSPPRA AAAGGSSAWV ALRGAAGSRK ASPAEQEGAA 60 AGLLRRLLPF HSGSFSFQID SKGGVCGQSS CFRISNVVDG SGKGGAEILI QGTTAVELAS 120 GLHWYLKYWC GAHISWDKTG GAQLASIPSP GSLPRVQGKG VKIERPVPWN YYQNVVTSSY 180 SFVWWDWKRW EKEIDWMALQ GINLPLAFTG QESIWQKVFK SFNVTDRDLD DFFGGPAFLA 240 WARMGNLHGW GGPLSQNWLD QQLALQKKIL SRMIELGMVP VLPSFSGNVP AIFAKLFPSA 300 NITRLGDWNT VDANPKWCCT YLLDPSDSLF IDVGQAFIRQ QIKEYGDVTN IYNCDTFNEN 360 TPPTDEPAYI SSLGSAIYEA MSRGNKNAVW LMQGWLFYSD AAFWKEPQMK ALLHSVPIGK 420 MIVLDLFADV KPIWKVSSQF YGVPYIWCML HNFGGNIEMY GILDSISSGP IDARTSYNST 480 MIGVGMCMEG IEHNPVVYEL MSEMAFHNKK VEVEDWLKTY SCRRYGQANA DIEKAWRYLY 540 HTIYNCTDGI ADHNKDYIVE FPDISPSSVT YQVSKRRGMS ITRNHRRFFL SEVSGILPQP 600 HLWYSTKEAV KALELFLDAG STFSESLTYR YDLVDLTRQC LSKLANEVYL DAISLYQKKD 660 SHGLNAHARK FLEIIVDIDT LLAADDNFLL GPWLESAKSL AITEKERQQY EWNARTQVTM 720 WYDNTETEQS KLHDYANKFW SGLLKSYYLP RASKYFAYLT RSLQENRSFQ LEEWRKDWIS 780 YSNEWQSGKE VYAVKATGDA LAIARSLYRK YLRP* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-17 | 69 | 156 | 88 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-98 | 515 | 811 | 297 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 171 | 507 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 14 | 812 | 67 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 51 | 813 | 51 | 812 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 51 | 812 | 51 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002314048.1 | 0 | 48 | 812 | 38 | 805 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002465249.1 | 0 | 39 | 812 | 39 | 775 | hypothetical protein SORBIDRAFT_01g034960 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 95 | 802 | 201 | 867 | A Chain A, Crystal Structure Of The Third Repeat Domain Of Reelin |
| PDB | 2vcb_A | 0 | 95 | 802 | 201 | 867 | A Chain A, Crystal Structure Of The Third Repeat Domain Of Reelin |
| PDB | 2vca_A | 0 | 95 | 802 | 201 | 867 | A Chain A, Crystal Structure Of The Third Repeat Domain Of Reelin |
| PDB | 2vc9_A | 0 | 95 | 802 | 201 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 95 | 802 | 224 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
