Basic Information | |
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Species | Zea mays |
Cazyme ID | GRMZM2G061833_T01 |
Family | GT65 |
Protein Properties | Length: 605 Molecular Weight: 67203 Isoelectric Point: 9.5539 |
Chromosome | Chromosome/Scaffold: 1 Start: 208192636 End: 208200349 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT65 | 106 | 383 | 0 |
YLTARFLNRPLLMPSLSASLFYKEVDLLQPISFDKVFDFNKFNARCHGFGTGRRWTADRDLDQLQQSIGSNADDSEVIEIVGENPFLWPDHWPVKDYAKI FDCLVLVPEIETEVVKVISKIREAGQRARHEAGGSHSKQRRDSSTNPPVSYVAVHMRVEKDWMIHCKKWEQRSKSHEICSSKEEIIHKVSQITDLRRPVV VYLAVADSLLEDDSITSGWRVGMVAYEKKKLGVTDIYDRQPYLIKSAIDFEVCSRADVFVGNSFSTFSNLVVLSRTER |
Full Sequence |
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Protein Sequence Length: 605 Download |
MEEKSMDKFA ALISSFRYPG PRASGLHAPL KDVKNTLSVR SILKAPEKGT FRHTAKKTVR 60 HREGEVSGRE EKSIESRKLI FTRAKQYAEE YDALERASKF YNGKTYLTAR FLNRPLLMPS 120 LSASLFYKEV DLLQPISFDK VFDFNKFNAR CHGFGTGRRW TADRDLDQLQ QSIGSNADDS 180 EVIEIVGENP FLWPDHWPVK DYAKIFDCLV LVPEIETEVV KVISKIREAG QRARHEAGGS 240 HSKQRRDSST NPPVSYVAVH MRVEKDWMIH CKKWEQRSKS HEICSSKEEI IHKVSQITDL 300 RRPVVVYLAV ADSLLEDDSI TSGWRVGMVA YEKKKLGVTD IYDRQPYLIK SAIDFEVCSR 360 ADVFVGNSFS TFSNLVVLSR TERLYNLGKA SLCGENIGLS SYAYNVMGDD GEPQRWMTDM 420 SDTSLQSRPQ CSKPPCKKDQ MLAISPGLEL KGASKFYNGK TNSVADAAQP AKGTADPVNP 480 SPKKCKGFLS FGFSWTKSWS RRGATSSSEN FGKTLSAALT GSAQGNNRGG GNEHQGCQDP 540 AAHCLHLHRR SNTPGVSASP SGPGALRPQL ISVQMQSVSV AGVEDVAEST ASVSPREKRR 600 RSLQ* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11298 | O-FucT-2 | 0.007 | 195 | 373 | 194 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11302 | O-FucT-1 | 0.005 | 256 | 380 | 148 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
cd11299 | O-FucT_plant | 0.0001 | 206 | 389 | 204 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 2.0e-20 | 109 | 381 | 326 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
cd11296 | O-FucT_like | 1.0e-23 | 224 | 383 | 164 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACN28408.1 | 0 | 103 | 426 | 87 | 430 | unknown [Zea mays] |
EMBL | CAH40837.1 | 0 | 103 | 427 | 86 | 430 | protein-O-fucosyltransferase 1 [Oryza sativa] |
EMBL | CAH40838.1 | 0 | 107 | 426 | 90 | 429 | protein-O-fucosyltransferase 1 [Saccharum officinarum] |
RefSeq | NP_001147772.1 | 0 | 103 | 426 | 87 | 430 | protein-O-fucosyltransferase 1 [Zea mays] |
RefSeq | XP_002451612.1 | 0 | 103 | 426 | 87 | 430 | hypothetical protein SORBIDRAFT_04g004590 [Sorghum bicolor] |