Basic Information | |
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Species | Zea mays |
Cazyme ID | GRMZM2G098397_T01 |
Family | GH79 |
Protein Properties | Length: 576 Molecular Weight: 63309.7 Isoelectric Point: 5.1913 |
Chromosome | Chromosome/Scaffold: 3 Start: 124642615 End: 124647335 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 75 | 568 | 0 |
SDEFVCATIDWWPPEKCNYDQCPWERASVLNLDLTNPLLAKAIQAFSPLRIRVGGSLQDQVLYGTPNLGLPCDPFTKVSSGLFGFSQGCITLERWDDIND MFLKTGAVVTFGLNALRGRQQTRKGVWGGPWNSSNAREFIEYTVLKNYPIDSWEFGNELSGSGVGASVSAEQYGKDLVELQTIISELYGDSNKPLVVAPG GFYDQKWFAQLLDVSGPNVLNAMTHHIYNLGAGNDPQVPNRILNPQYLSRTSDTFRSLQLTIQRHGPWSAPWVGESGGAYNSGSRLVSNTFLNSFWYLDQ LGQSAKYDTKVYCRQTLIGGNYGLLDTETFVPNPDYYSALLWHQLMGTGVLSVDISGSSYLRAYVHCAKQKGGVTLLLLNLHRTMGFMVSVRNDLNVNLA EGQGIRRDSAFVHGLKRTVSWVGSKASDGFSKREEYHLSSKDGNPFARTMLLNGAPLELTEDGGIPSLYPVEVSVNSPIYVAPLTIAFVVFPDF |
Full Sequence |
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Protein Sequence Length: 576 Download |
MLTISFPESI LAYRDTTVID CLIPALLPSD SGSGSMRLWS LFLLPLLCLP ARVRSEDYAD 60 ATVIVRGSET IASTSDEFVC ATIDWWPPEK CNYDQCPWER ASVLNLDLTN PLLAKAIQAF 120 SPLRIRVGGS LQDQVLYGTP NLGLPCDPFT KVSSGLFGFS QGCITLERWD DINDMFLKTG 180 AVVTFGLNAL RGRQQTRKGV WGGPWNSSNA REFIEYTVLK NYPIDSWEFG NELSGSGVGA 240 SVSAEQYGKD LVELQTIISE LYGDSNKPLV VAPGGFYDQK WFAQLLDVSG PNVLNAMTHH 300 IYNLGAGNDP QVPNRILNPQ YLSRTSDTFR SLQLTIQRHG PWSAPWVGES GGAYNSGSRL 360 VSNTFLNSFW YLDQLGQSAK YDTKVYCRQT LIGGNYGLLD TETFVPNPDY YSALLWHQLM 420 GTGVLSVDIS GSSYLRAYVH CAKQKGGVTL LLLNLHRTMG FMVSVRNDLN VNLAEGQGIR 480 RDSAFVHGLK RTVSWVGSKA SDGFSKREEY HLSSKDGNPF ARTMLLNGAP LELTEDGGIP 540 SLYPVEVSVN SPIYVAPLTI AFVVFPDFEA EACGR* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 59 | 376 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACG27548.1 | 0 | 36 | 575 | 1 | 540 | heparanase-like protein 2 precursor [Zea mays] |
GenBank | ACR34666.1 | 0 | 1 | 575 | 1 | 575 | unknown [Zea mays] |
GenBank | EEC69565.1 | 0 | 35 | 575 | 670 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
RefSeq | NP_001130921.1 | 0 | 11 | 575 | 1 | 566 | hypothetical protein LOC100192026 [Zea mays] |
RefSeq | XP_002442385.1 | 0 | 51 | 575 | 16 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0001 | 125 | 439 | 75 | 383 | A Chain A, Structural Basis For The Defects Of Human Lung Cancer Somatic Mutations In The Repression Activity Of Keap1 On Nrf2 |
PDB | 3vnz_A | 0.0001 | 125 | 439 | 75 | 383 | A Chain A, Structural Basis For The Defects Of Human Lung Cancer Somatic Mutations In The Repression Activity Of Keap1 On Nrf2 |
PDB | 3vny_A | 0.0001 | 125 | 439 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |