| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G098397_T02 |
| Family | GH79 |
| Protein Properties | Length: 567 Molecular Weight: 62431.7 Isoelectric Point: 5.6626 |
| Chromosome | Chromosome/Scaffold: 3 Start: 124642514 End: 124647277 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 66 | 559 | 0 |
| SDEFVCATIDWWPPEKCNYDQCPWERASVLNLDLTNPLLAKAIQAFSPLRIRVGGSLQDQVLYGTPNLGLPCDPFTKVSSGLFGFSQGCITLERWDDIND MFLKTGAVVTFGLNALRGRQQTRKGVWGGPWNSSNAREFIEYTVLKNYPIDSWEFGNELSGSGVGASVSAEQYGKDLVELQTIISELYGDSNKPLVVAPG GFYDQKWFAQLLDVSGPNVLNAMTHHIYNLGAGNDPQVPNRILNPQYLSRTSDTFRSLQLTIQRHGPWSAPWVGESGGAYNSGSRLVSNTFLNSFWYLDQ LGQSAKYDTKVYCRQTLIGGNYGLLDTETFVPNPDYYSALLWHQLMGTGVLSVDISGSSYLRAYVHCAKQKGGVTLLLLNLHRTMGFMVSVRNDLNVNLA EGQGIRRDSAFVHGLKRTVSWVGSKASDGFSKREEYHLSSKDGNPFARTMLLNGAPLELTEDGGIPSLYPVEVSVNSPIYVAPLTIAFVVFPDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 567 Download |
| MEHVDPISLG PWIPSLRPTP FQGSGSMRLW SLFLLPLLCL PARVRSEDYA DATVIVRGSE 60 TIASTSDEFV CATIDWWPPE KCNYDQCPWE RASVLNLDLT NPLLAKAIQA FSPLRIRVGG 120 SLQDQVLYGT PNLGLPCDPF TKVSSGLFGF SQGCITLERW DDINDMFLKT GAVVTFGLNA 180 LRGRQQTRKG VWGGPWNSSN AREFIEYTVL KNYPIDSWEF GNELSGSGVG ASVSAEQYGK 240 DLVELQTIIS ELYGDSNKPL VVAPGGFYDQ KWFAQLLDVS GPNVLNAMTH HIYNLGAGND 300 PQVPNRILNP QYLSRTSDTF RSLQLTIQRH GPWSAPWVGE SGGAYNSGSR LVSNTFLNSF 360 WYLDQLGQSA KYDTKVYCRQ TLIGGNYGLL DTETFVPNPD YYSALLWHQL MGTGVLSVDI 420 SGSSYLRAYV HCAKQKGGVT LLLLNLHRTM GFMVSVRNDL NVNLAEGQGI RRDSAFVHGL 480 KRTVSWVGSK ASDGFSKREE YHLSSKDGNP FARTMLLNGA PLELTEDGGI PSLYPVEVSV 540 NSPIYVAPLT IAFVVFPDFE AEACGR* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 50 | 367 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG27548.1 | 0 | 27 | 566 | 1 | 540 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACR34666.1 | 0 | 1 | 566 | 11 | 575 | unknown [Zea mays] |
| GenBank | EEC69565.1 | 0 | 26 | 566 | 670 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
| RefSeq | NP_001130921.1 | 0 | 1 | 566 | 1 | 566 | hypothetical protein LOC100192026 [Zea mays] |
| RefSeq | XP_002442385.1 | 0 | 42 | 566 | 16 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0001 | 154 | 430 | 115 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.0001 | 154 | 430 | 115 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.0001 | 154 | 430 | 115 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
