| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G107815_T01 |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 60341.8 Isoelectric Point: 8.5678 |
| Chromosome | Chromosome/Scaffold: 1 Start: 25410357 End: 25414879 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 42 | 535 | 0 |
| DDNYVCATIDWWPPEKCNYNQCPWGQASILNLDLDHPFLAQAIQAFDHLRIRLGGSLQDRVVYDVGTESPCSPFTNVSNALFGFSVGCLGMDRWDKLNDL FERTGAIVTFGVNALYGRYNVRRSIWAGKWNSTNAYDFVKYTISKGYPVGSWEFGNELSGHGIGAKVDAKLYGKDVIEFKSILRQLYKAPLSQPLLLAPG GFFDQQWYSQLLETSGHGVVNALSHHVYNLGGGNDVHLIRKILDPKYLDRAEDTYRDMQLTIQRHGTWASAWVSESGGVFNNGGQLVSNTFINSIWYLDQ LGMASKYNTKVFCRQTLIGGNYGLLDTQTFLPNPDYYSALLWHRLMGNGVLSVDINAPRQIRAYAHCRKQQQGITILLINLSNTTGYNVTLQNDINVSLG KRPDLEKRSSFTHRLRKAVSWLGRKPASNTRRREEYHLTAKDGDLQSKTMLLNGAPLELGDAGSIPAMDPVLVAVDLPVQLAPTSIAFVVLPKF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MELRRLLLLA LICLRAPRLA SAQQPDEATV IVKGSTRIAE TDDNYVCATI DWWPPEKCNY 60 NQCPWGQASI LNLDLDHPFL AQAIQAFDHL RIRLGGSLQD RVVYDVGTES PCSPFTNVSN 120 ALFGFSVGCL GMDRWDKLND LFERTGAIVT FGVNALYGRY NVRRSIWAGK WNSTNAYDFV 180 KYTISKGYPV GSWEFGNELS GHGIGAKVDA KLYGKDVIEF KSILRQLYKA PLSQPLLLAP 240 GGFFDQQWYS QLLETSGHGV VNALSHHVYN LGGGNDVHLI RKILDPKYLD RAEDTYRDMQ 300 LTIQRHGTWA SAWVSESGGV FNNGGQLVSN TFINSIWYLD QLGMASKYNT KVFCRQTLIG 360 GNYGLLDTQT FLPNPDYYSA LLWHRLMGNG VLSVDINAPR QIRAYAHCRK QQQGITILLI 420 NLSNTTGYNV TLQNDINVSL GKRPDLEKRS SFTHRLRKAV SWLGRKPASN TRRREEYHLT 480 AKDGDLQSKT MLLNGAPLEL GDAGSIPAMD PVLVAVDLPV QLAPTSIAFV VLPKFEAKAC 540 S* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 343 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 1 | 541 | 1 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACV84153.1 | 0 | 1 | 541 | 1 | 542 | heparanase [Oryza sativa Indica Group] |
| RefSeq | NP_001049350.1 | 0 | 1 | 541 | 1 | 541 | Os03g0211700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001145968.1 | 0 | 1 | 541 | 1 | 541 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | XP_002468296.1 | 0 | 12 | 541 | 14 | 543 | hypothetical protein SORBIDRAFT_01g043180 [Sorghum bicolor] |
