| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G107815_T02 |
| Family | GH79 |
| Protein Properties | Length: 432 Molecular Weight: 47941.8 Isoelectric Point: 8.4446 |
| Chromosome | Chromosome/Scaffold: 1 Start: 25410357 End: 25414879 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 86 | 425 | 0 |
| GNELSGHGIGAKVDAKLYGKDVIEFKSILRQLYKAPLSQPLLLAPGGFFDQQWYSQLLETSGHGVVNALSHHVYNLGGGNDVHLIRKILDPKYLDRAEDT YRDMQLTIQRHGTWASAWVSESGGVFNNGGQLVSNTFINSIWYLDQLGMASKYNTKVFCRQTLIGGNYGLLDTQTFLPNPDYYSALLWHRLMGNGVLSVD INAPRQIRAYAHCRKQQQGITILLINLSNTTGYNVTLQNDINVSLGKRPDLEKRSSFTHRLRKAVSWLGRKPASNTRRREEYHLTAKDGDLQSKTMLLNG APLELGDAGSIPAMDPVLVAVDLPVQLAPTSIAFVVLPKF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 432 Download |
| MELRRLLLLA LICLRAPRLA SAQQPDEATV IVKGSTRIAE TDDNYVCATI DWWPPEKCNY 60 NQCPWGQASI LNLDLDHPFL AQAIQGNELS GHGIGAKVDA KLYGKDVIEF KSILRQLYKA 120 PLSQPLLLAP GGFFDQQWYS QLLETSGHGV VNALSHHVYN LGGGNDVHLI RKILDPKYLD 180 RAEDTYRDMQ LTIQRHGTWA SAWVSESGGV FNNGGQLVSN TFINSIWYLD QLGMASKYNT 240 KVFCRQTLIG GNYGLLDTQT FLPNPDYYSA LLWHRLMGNG VLSVDINAPR QIRAYAHCRK 300 QQQGITILLI NLSNTTGYNV TLQNDINVSL GKRPDLEKRS SFTHRLRKAV SWLGRKPASN 360 TRRREEYHLT AKDGDLQSKT MLLNGAPLEL GDAGSIPAMD PVLVAVDLPV QLAPTSIAFV 420 VLPKFEAKAC S* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 8.0e-33 | 25 | 85 | 61 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-85 | 86 | 233 | 148 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 4e-39 | 16 | 85 | 16 | 85 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACG44916.1 | 0 | 86 | 431 | 196 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACN26863.1 | 0 | 1 | 431 | 1 | 431 | unknown [Zea mays] |
| RefSeq | NP_001145968.1 | 4e-39 | 16 | 85 | 16 | 85 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | NP_001145968.1 | 0 | 86 | 431 | 196 | 541 | hypothetical protein LOC100279495 [Zea mays] |
