| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G148167_T01 |
| Family | GH79 |
| Protein Properties | Length: 544 Molecular Weight: 58269.6 Isoelectric Point: 9.4498 |
| Chromosome | Chromosome/Scaffold: 6 Start: 123344103 End: 123346790 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 45 | 537 | 0 |
| ENFVCATLDWWPPDKCDYGTCPWGRAGLLNLDLSNKVLLNAVRAFSPPLMLRLGGSLQDKVVYGTADLGRPCAPFAKNASEMHGFTQGCLTLRRWDELNA FFQKSGARIVFGINALNGRVPLPDGSMGGPWDYTNAASLIRYTANKGYRIHGWELGNELSGTGVGARVGAEQYGADVIALKTLVDDIYASHPSKPLVLAP GGFFDQAWFAQLIVRTRPNLLDVITHHIYNLGPGRDTHLIDKILNPSVLDGMRSTFSSLQGLLKSAGTSTVAWVGEAGGAYNSGRHLVTDAFVFSFWFLD QLGMSAKYDTKSYCRQSLIGGNYGLLNTTTFQPNPDYYSALLWHRLMGTKVLATTFSGTNKIRAYAHCARDSPGITLLLINLSGNTTTQVSVSVTTQGAV AAHKHGARKHVGGRKFRHVHVPSFDEAAGGVRDEYHLTPKDGNLRSQIMLLNGRALATDTAGNIPALEAVKMDAAQPIAVAPYSIVFARISHF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 544 Download |
| MAAAGTQLGR LLVGGLWLLA ALLQRGAAAA VAAVDGRRAI AATGENFVCA TLDWWPPDKC 60 DYGTCPWGRA GLLNLDLSNK VLLNAVRAFS PPLMLRLGGS LQDKVVYGTA DLGRPCAPFA 120 KNASEMHGFT QGCLTLRRWD ELNAFFQKSG ARIVFGINAL NGRVPLPDGS MGGPWDYTNA 180 ASLIRYTANK GYRIHGWELG NELSGTGVGA RVGAEQYGAD VIALKTLVDD IYASHPSKPL 240 VLAPGGFFDQ AWFAQLIVRT RPNLLDVITH HIYNLGPGRD THLIDKILNP SVLDGMRSTF 300 SSLQGLLKSA GTSTVAWVGE AGGAYNSGRH LVTDAFVFSF WFLDQLGMSA KYDTKSYCRQ 360 SLIGGNYGLL NTTTFQPNPD YYSALLWHRL MGTKVLATTF SGTNKIRAYA HCARDSPGIT 420 LLLINLSGNT TTQVSVSVTT QGAVAAHKHG ARKHVGGRKF RHVHVPSFDE AAGGVRDEYH 480 LTPKDGNLRS QIMLLNGRAL ATDTAGNIPA LEAVKMDAAQ PIAVAPYSIV FARISHFNAP 540 ACS* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 43 | 347 | 305 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF81144.1 | 0 | 1 | 543 | 1 | 543 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 0 | 10 | 543 | 4 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| RefSeq | NP_001132339.1 | 0 | 1 | 543 | 1 | 543 | hypothetical protein LOC100193781 [Zea mays] |
| RefSeq | NP_001152083.1 | 0 | 1 | 542 | 1 | 548 | heparanase-like protein 3 [Zea mays] |
| RefSeq | XP_002437942.1 | 0 | 1 | 543 | 1 | 554 | hypothetical protein SORBIDRAFT_10g005260 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 56 | 444 | 36 | 418 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt85h2- Insights Into The Structural Basis Of A Multifunctional (Iso) Flavonoid Glycosyltransferase |
| PDB | 3vnz_A | 0.0002 | 56 | 444 | 36 | 418 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt85h2- Insights Into The Structural Basis Of A Multifunctional (Iso) Flavonoid Glycosyltransferase |
| PDB | 3vny_A | 0.0002 | 56 | 444 | 36 | 418 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
