| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G311342_T02 |
| Family | GH79 |
| Protein Properties | Length: 263 Molecular Weight: 29440.6 Isoelectric Point: 10.2324 |
| Chromosome | Chromosome/Scaffold: 3 Start: 204274372 End: 204277006 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 35 | 210 | 0 |
| LLGCLPLRRWDELNVFLQKTRPRIVFGLNALNGRVPMPDDSLGGPWNYTNAASFIRYTVSKGYDVHGWELGNELSGSGVRARIDADQYAADVIALKHIVD SAYQGKPSKPLVLASGGFFDAVWFTQLVSKTKPDQMDAITHHIYNLGPGVDDHLVQKILDPSYLDGKASTFSNFQQ | |||
| Full Sequence |
|---|
| Protein Sequence Length: 263 Download |
| MARVRETQPW RHRPQAQALA AARHQAPVPP AGVVLLGCLP LRRWDELNVF LQKTRPRIVF 60 GLNALNGRVP MPDDSLGGPW NYTNAASFIR YTVSKGYDVH GWELGNELSG SGVRARIDAD 120 QYAADVIALK HIVDSAYQGK PSKPLVLASG GFFDAVWFTQ LVSKTKPDQM DAITHHIYNL 180 GPGVDDHLVQ KILDPSYLDG KASTFSNFQQ PSGDTQVRRH VRCRLGWRGW RHVSGSALVR 240 HKELLQTDLG WRQLWPAQHK YI* 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 8.0e-102 | 37 | 210 | 174 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACR36272.1 | 0 | 23 | 209 | 120 | 313 | unknown [Zea mays] |
| GenBank | EAY87898.1 | 0 | 37 | 209 | 138 | 310 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
| RefSeq | NP_001048420.1 | 0 | 37 | 209 | 138 | 310 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001056967.1 | 0 | 37 | 209 | 129 | 301 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002452991.1 | 0 | 37 | 209 | 138 | 310 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
| Hydropathy |
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