| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G480451_T02 |
| Family | GH79 |
| Protein Properties | Length: 1014 Molecular Weight: 114267 Isoelectric Point: 7.3829 |
| Chromosome | Chromosome/Scaffold: 1 Start: 158479095 End: 158501168 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 515 | 1006 | 0 |
| EFVCATIDWWPPEKCNYDQCPWGRASVLNLDLTNPLLAKAIQAFSPLRIRVGGSLQDQVLYGTPNLGLPCDPFTKVSSGLFEFSQGCITLERWDDINDLF LNTGAVVTFGLNALQGRHQIRKGVWGGPWNSSNAREFIEYTASKNYPIDSWEFGNELSGSGVGASVAAEQYGKDLVVLQTIVNELYGDSSKPLVVAPGGF YDQKWFAQLLEASGPNVLNAVTHHIYNLGAGDDPQVPNRILSPQYLSRTSDIFRGLQLTIQRHGPWSAPWVGESGGAYNSGSRLVSNTFLNSFWYLDQLG QSAKYDTKVYCRQTLIGGNYGLLDTDTFVPNPDYYSALLWHRLMGTGVLSLDISGSPYLRPYAHCAKQKGGIALVLLNLHRTMGFMVSVRNDINVNLAEG QGIRRDNAFVHGLKRTVSWVGSKASDGFSKREEYHLSAQDGNPFARTMLLNGVPLELTEDGDIPPLYPVEVSANSPIYVAPLTIAFVVFPDF | |||
| Full Sequence |
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| Protein Sequence Length: 1014 Download |
| MHLSKSARRQ TTMHLGRRTS WQAKVHRCVM MMTMGRTTME RPMTRLLQRH RQQTSVGSRS 60 RTSTARESEL DEQLRQQQQQ VQQLSQQVQM MQMYSAQMVS QMGPQFTRPS QSGQTPNTNE 120 THGSETGQGN PQMDMRWSMP PRGQILPPPQ LGMGYWSPPP WGYPTHPMGP WGRPHGQHSH 180 FHHQRSMSPG YFTNLLNRDN DDVFILDENM GNENEVMESE SPPMNDMISQ SKPKGRSKNF 240 NEAEDILLIS SYLNISKDAV VGRDQKDGRF WERVEKYFHD NKTFESERNW SSLKHRWSTI 300 HKEVSLFQGF VDAVERKNES GKTMSDKLAQ ANTMFQELKG KAFSLFHAWN ILKDEPKWAE 360 EKISKEYNAN GEDHPNSERP LGRKAEKEKA KGKKRSEEEH DPFIDEVKKM RESLRANERN 420 VMKGSTINYY PRSTTACRCV PEMKVAILAD AEWWLLPGGD QREYTRWNIG SGSMRLWCIF 480 LLPLLCQLAG VRSEDYSDVT VIVRGSETIA STSGEFVCAT IDWWPPEKCN YDQCPWGRAS 540 VLNLDLTNPL LAKAIQAFSP LRIRVGGSLQ DQVLYGTPNL GLPCDPFTKV SSGLFEFSQG 600 CITLERWDDI NDLFLNTGAV VTFGLNALQG RHQIRKGVWG GPWNSSNARE FIEYTASKNY 660 PIDSWEFGNE LSGSGVGASV AAEQYGKDLV VLQTIVNELY GDSSKPLVVA PGGFYDQKWF 720 AQLLEASGPN VLNAVTHHIY NLGAGDDPQV PNRILSPQYL SRTSDIFRGL QLTIQRHGPW 780 SAPWVGESGG AYNSGSRLVS NTFLNSFWYL DQLGQSAKYD TKVYCRQTLI GGNYGLLDTD 840 TFVPNPDYYS ALLWHRLMGT GVLSLDISGS PYLRPYAHCA KQKGGIALVL LNLHRTMGFM 900 VSVRNDINVN LAEGQGIRRD NAFVHGLKRT VSWVGSKASD GFSKREEYHL SAQDGNPFAR 960 TMLLNGVPLE LTEDGDIPPL YPVEVSANSP IYVAPLTIAF VVFPDFEAEA CGR* 1020 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam14303 | NAM-associated | 8.0e-5 | 341 | 380 | 40 | + No apical meristem-associated C-terminal domain. This domain is found in a number of different types of plant proteins including NAM-like proteins. | ||
| pfam03662 | Glyco_hydro_79n | 0 | 498 | 814 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG27548.1 | 0 | 489 | 1013 | 16 | 540 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACR34666.1 | 0 | 470 | 1013 | 32 | 575 | unknown [Zea mays] |
| GenBank | EEC69565.1 | 0 | 451 | 1013 | 644 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
| RefSeq | NP_001130921.1 | 0 | 470 | 1013 | 23 | 566 | hypothetical protein LOC100192026 [Zea mays] |
| RefSeq | XP_002442385.1 | 0 | 489 | 1013 | 16 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
| Hydropathy |
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