| Basic Information | |
|---|---|
| Species | Vitis vinifera |
| Cazyme ID | GSVIVT01007826001 |
| Family | GH89 |
| Protein Properties | Length: 847 Molecular Weight: 96325.6 Isoelectric Point: 6.0533 |
| Chromosome | Chromosome/Scaffold: 17 Start: 8646692 End: 8660814 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH89 | 97 | 439 | 0 |
| PEILITGVTGVEIMAGLHWYLKYWCGSHISWDKTGGAQLLSVPDSGSFPRVQEAGILIQRPIPWNYYQNAVTSSYTFAWWDWKRWEKEIDWMALQGINLP LAFTGQEAIWQKVFRNFNISHLDLKDFFGGPAFLSWSRMGNLHGWGGPLPQSWLDQQLLLQKKILARMYELGMTPVLPAFSGNVPAALKYIFPSAKITRL GNWFTVGGNPRWCCTYLLDATDPLFIEIGKAFIQQQLKEYGRTGHIYNCDTFDENTPPVDDPEYISSLGAAIFRGMQSGDSNAIWLMQGWLFSYDPFWRP PQMKALLHSVPMGRLVVLDLFAEVKPIWITSEQFYGVPYIWKV | |||
| GH89 | 468 | 836 | 0 |
| VLCMLHNFAGNIEMYGILDAVASGPILLRAKYAESAVVGVGMSMEGIEQNPVVYDLMSEMAFQHSKVDVKVWIALYSTRRYGKSVPEIQDAWNILYHTVY NCTDGSYDKNRDVIVAFPDIDPSFIPTPKLSMPGGYHRYGKSVSRRTVLKEITNSFEQPHLWYSTSEVKDALGLFIASGGQLLGSNTYRYDLVDLTRQAL AKYANQLFLEVIEAYQLNDVRGAACHSQKFLELVEDMDTLLACHDGFLLGPWLESAKQLAQDEQQEIQFEWNARTQITMWFDNTEDEASLLRDYGNKYWS GLLRDYYGPRAAIYFKYLLESLETGNEFALKDWRREWIKLTNDWQNSRNAYPVRSSGNAIDTSRRLYNK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 847 Download |
| MASPFAAVSL SFFLFSFLSF AQSSTIGVTY ISRLLEIQDR ERAPPSVQIA AAYGVLHRLL 60 PSHSSSFEFG IVSKEQCGGD SCFMISNHPS SSGHGAPEIL ITGVTGVEIM AGLHWYLKYW 120 CGSHISWDKT GGAQLLSVPD SGSFPRVQEA GILIQRPIPW NYYQNAVTSS YTFAWWDWKR 180 WEKEIDWMAL QGINLPLAFT GQEAIWQKVF RNFNISHLDL KDFFGGPAFL SWSRMGNLHG 240 WGGPLPQSWL DQQLLLQKKI LARMYELGMT PVLPAFSGNV PAALKYIFPS AKITRLGNWF 300 TVGGNPRWCC TYLLDATDPL FIEIGKAFIQ QQLKEYGRTG HIYNCDTFDE NTPPVDDPEY 360 ISSLGAAIFR GMQSGDSNAI WLMQGWLFSY DPFWRPPQMK ALLHSVPMGR LVVLDLFAEV 420 KPIWITSEQF YGVPYIWKVT KSGRQQSLKF TNEKCCSFFR SHSPDSEVLC MLHNFAGNIE 480 MYGILDAVAS GPILLRAKYA ESAVVGVGMS MEGIEQNPVV YDLMSEMAFQ HSKVDVKVWI 540 ALYSTRRYGK SVPEIQDAWN ILYHTVYNCT DGSYDKNRDV IVAFPDIDPS FIPTPKLSMP 600 GGYHRYGKSV SRRTVLKEIT NSFEQPHLWY STSEVKDALG LFIASGGQLL GSNTYRYDLV 660 DLTRQALAKY ANQLFLEVIE AYQLNDVRGA ACHSQKFLEL VEDMDTLLAC HDGFLLGPWL 720 ESAKQLAQDE QQEIQFEWNA RTQITMWFDN TEDEASLLRD YGNKYWSGLL RDYYGPRAAI 780 YFKYLLESLE TGNEFALKDW RREWIKLTND WQNSRNAYPV RSSGNAIDTS RRLYNKYLQD 840 PEIYDL* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-20 | 48 | 128 | 81 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 3.0e-101 | 539 | 837 | 299 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 9.0e-166 | 162 | 531 | 370 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 1 | 846 | 1 | 846 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 30 | 843 | 32 | 812 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 1 | 846 | 1 | 813 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 22 | 845 | 25 | 811 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 842 | 1 | 804 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 74 | 823 | 195 | 862 | A Chain A, Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31 |
| PDB | 2vcb_A | 0 | 74 | 823 | 195 | 862 | A Chain A, Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31 |
| PDB | 2vca_A | 0 | 74 | 823 | 195 | 862 | A Chain A, Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31 |
| PDB | 2vc9_A | 0 | 74 | 823 | 195 | 862 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 74 | 823 | 218 | 885 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
