| Basic Information | |
|---|---|
| Species | Vitis vinifera |
| Cazyme ID | GSVIVT01012184001 |
| Family | GH79 |
| Protein Properties | Length: 525 Molecular Weight: 58147 Isoelectric Point: 5.1701 |
| Chromosome | Chromosome/Scaffold: 1 Start: 721721 End: 725418 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 41 | 518 | 0 |
| DDNFICATIDWWPADKCDYNQCPWGLAGIFNLDLQNIILVNAIKAFDNLRIRMGGSLQDQILYQIGYAIHDCPQIKKVEGGLFGFSEGCLTMQKWDEVNK LINQTGALFTFGLNALIGKNKPEPPPKGDNITWTGDWDSQNARDLIEYTLSKGYKIDSYELGNELCGSGVSARLDAKQYAKDLVKLRQTVKDVYQKARPM PKIMGPAGFYDKEWFDTFLEAAGPHAVDGLSHHTYNLGPGVDPTLINKVQDPYFLSQIAQTYKDISDSIRLFGPWASAWIGEAGGAYNSGGKDVSHTFAN GFWYLDQLGMSASFNHKVFCRQSLIGGNYGLLDTTSFIPNPDYYGALLWHRLMGKRVLSTSQNDSPYLRVYSHCAKQKPGISMLIINMSNSTWFQVQVQN DMNLHPTASESNGGQEREEYHLTPQNGDIQSDKLLLNGNLLSLTEASDIPEMKPKLVDPSSAIVVAPDSFVYATLRDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 525 Download |
| MPMGVKGTMV GVLLFCAWFF EGFAEDVKVT VGGVTSIAET DDNFICATID WWPADKCDYN 60 QCPWGLAGIF NLDLQNIILV NAIKAFDNLR IRMGGSLQDQ ILYQIGYAIH DCPQIKKVEG 120 GLFGFSEGCL TMQKWDEVNK LINQTGALFT FGLNALIGKN KPEPPPKGDN ITWTGDWDSQ 180 NARDLIEYTL SKGYKIDSYE LGNELCGSGV SARLDAKQYA KDLVKLRQTV KDVYQKARPM 240 PKIMGPAGFY DKEWFDTFLE AAGPHAVDGL SHHTYNLGPG VDPTLINKVQ DPYFLSQIAQ 300 TYKDISDSIR LFGPWASAWI GEAGGAYNSG GKDVSHTFAN GFWYLDQLGM SASFNHKVFC 360 RQSLIGGNYG LLDTTSFIPN PDYYGALLWH RLMGKRVLST SQNDSPYLRV YSHCAKQKPG 420 ISMLIINMSN STWFQVQVQN DMNLHPTASE SNGGQEREEY HLTPQNGDIQ SDKLLLNGNL 480 LSLTEASDIP EMKPKLVDPS SAIVVAPDSF VYATLRDFKA PTCM* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 24 | 349 | 326 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN63833.1 | 0 | 1 | 508 | 1 | 501 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI27258.1 | 0 | 1 | 524 | 1 | 524 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 3 | 524 | 1 | 522 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 9 | 523 | 1 | 517 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 24 | 522 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000000003 | 129 | 412 | 115 | 383 | A Chain A, Crystal Structure Of 26s Proteasome Subunit Rpn2 |
| PDB | 3vnz_A | 0.000000003 | 129 | 412 | 115 | 383 | A Chain A, Crystal Structure Of 26s Proteasome Subunit Rpn2 |
| PDB | 3vny_A | 0.000000003 | 129 | 412 | 115 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
