| Basic Information | |
|---|---|
| Species | Vitis vinifera |
| Cazyme ID | GSVIVT01016856001 |
| Family | AA3 |
| Protein Properties | Length: 594 Molecular Weight: 65190.6 Isoelectric Point: 8.9794 |
| Chromosome | Chromosome/Scaffold: 9 Start: 2027678 End: 2032205 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 51 | 585 | 0 |
| PSASLSGSHNTYDYIIVGGGTAGCPLAATLSQNFSVLLLERGGAPFDNVNVSYLKNFHISLADTSPTSASQAFISTDGVFNSRARVLGGGTCINAGFYTR ASTRYIEEAGWDAKLVNESYPWIERQIVQQPKLAPWQKALRDGLLEVGISPFNGFTFDHLYGTKVGGTIFDEFGKRHTAADLLAEGNPEKLSVLIYAKVQ KIMFNTTAKRPKAVGVIFKDENGNQHQAFLAERRGSEIILSCGAIGSPQMLMLSGIGPKAELKKFNISVVLNNRFVGKGLSDNPLNTVFVPTDRPVEQSL IQTVGITKRGVYIEASSGFGQSSDSIRYDHGMMSAEIGQLSTIPPRQRTAQAIQDYAAGKQFLPHEAFMGGFILEKIASPFSKGHLKLINTNVDDNPSIT FNYFSHPYDLQRCVEGIRMMEKIVRTQHFMNYTQCDDTTLDKLLNMSVKANINLVPKHTNDTKSMEQFCKDTVITIWHYHGGCHVGKVVDHKYKVLGVHR LRVIDGSTFRESPGTNPQATVMMMGRYMGLKILRE | |||
| Full Sequence |
|---|
| Protein Sequence Length: 594 Download |
| MDLVGAVKLF LLCSLLWLSA ITSCQGLCKE NSSEYPYPFI RRASSFSSSS PSASLSGSHN 60 TYDYIIVGGG TAGCPLAATL SQNFSVLLLE RGGAPFDNVN VSYLKNFHIS LADTSPTSAS 120 QAFISTDGVF NSRARVLGGG TCINAGFYTR ASTRYIEEAG WDAKLVNESY PWIERQIVQQ 180 PKLAPWQKAL RDGLLEVGIS PFNGFTFDHL YGTKVGGTIF DEFGKRHTAA DLLAEGNPEK 240 LSVLIYAKVQ KIMFNTTAKR PKAVGVIFKD ENGNQHQAFL AERRGSEIIL SCGAIGSPQM 300 LMLSGIGPKA ELKKFNISVV LNNRFVGKGL SDNPLNTVFV PTDRPVEQSL IQTVGITKRG 360 VYIEASSGFG QSSDSIRYDH GMMSAEIGQL STIPPRQRTA QAIQDYAAGK QFLPHEAFMG 420 GFILEKIASP FSKGHLKLIN TNVDDNPSIT FNYFSHPYDL QRCVEGIRMM EKIVRTQHFM 480 NYTQCDDTTL DKLLNMSVKA NINLVPKHTN DTKSMEQFCK DTVITIWHYH GGCHVGKVVD 540 HKYKVLGVHR LRVIDGSTFR ESPGTNPQAT VMMMGRYMGL KILRERLGAA AGV* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam05199 | GMC_oxred_C | 5.0e-28 | 430 | 575 | 151 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| TIGR03970 | Rv0697 | 1.0e-29 | 63 | 575 | 570 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR01810 | betA | 1.0e-29 | 63 | 575 | 564 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 6.0e-45 | 59 | 591 | 578 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 20 | 593 | 574 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN78644.1 | 0 | 1 | 591 | 1 | 609 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI35951.1 | 0 | 1 | 593 | 1 | 593 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002275841.1 | 0 | 8 | 593 | 4 | 584 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002327436.1 | 0 | 60 | 593 | 15 | 547 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002329018.1 | 0 | 33 | 593 | 30 | 591 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1ju2_B | 0 | 45 | 586 | 13 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 1ju2_A | 0 | 45 | 586 | 13 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_B | 0 | 45 | 586 | 13 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_A | 0 | 45 | 586 | 13 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdn_B | 0 | 45 | 586 | 13 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cutin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
| cutin biosynthesis | RXN-9802 | EC-1.1.1 | 16-hydroxypalmitate dehydrogenase |
| suberin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
