| Basic Information | |
|---|---|
| Species | Vitis vinifera |
| Cazyme ID | GSVIVT01032165001 |
| Family | GH89 |
| Protein Properties | Length: 869 Molecular Weight: 99572 Isoelectric Point: 7.2887 |
| Chromosome | Chromosome/Scaffold: 13 Start: 21901208 End: 21926021 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 155 | 865 | 0 |
| GPEIMIKGTTAVEIASGLHWYIKYWCGAHVSWDKTGSIQIASIPKPGSLPLVKDEGVLIQRPVPWNYYQNVVTSSYSYVWWDWERWEKEIDWMALQGVNL PLAFNGQEAIWQKVFMDFNISKKDLNGFFGGPAFLAWARMGNLHGWGGPLSQNWLDEQLVLQKQILCRMLELGMTPVLPSFSGNVPEALKKIFPSANITR LGEWNTVDNNTRWCCTYLLDASDPLFIQIGKAFIRQQIKEYGDVTDIYNCDTFNENSPPTNDPAYISSLGAAIYKAMSQGDKDSVWLMQGWLFYSDSGFW KPPQMKALLHSVPFGKMVVLDLFADAKPIWRTSSQFYGTPYIWCMLHNFGGNIEMYGILDAVSSGPVDARISKNSTMVGVGMCMEGIEQNPVAYELMSEM AFRSEKVQLVEWLKTYSYRRYGKAVHHVEAAWEILYRTIYNCTDGIADHNTDFMVNFPDWDPSLNPSSDISKEQHIIQKILTQTGRRKILFQETSSDLPQ SHLWYSTHEVVNALRLFLDAGNELSKSSTYRYDLVDLTRQVLSKLGNQVYLDAVIAFRQKDAKNFHLHSQKFVQLVKDIDTLLASDDNFLLGTWLESAKK LAVNPREMEQYEWNARTQLTMWFYVTKTNQSKLHDYANKFWSGLLENYYLPRASMYFSYLAKALTENKNFKLEEWRREWISYSNKWQAGKELYPVRAKGD TLAISRALYEK | |||
| Full Sequence |
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| Protein Sequence Length: 869 Download |
| MLDKSHIDSM QPQSTPTYDQ NVGSLTSLLF TIRLLLLGLF SIFIINHLTL RHSTISSLNY 60 NPFQTMSKFL LWVLMLLPFL PLSSSSHSEA IEALLSRLAT KRAAPSVQES AAKAVLQRLL 120 PTHLDSFQFE IVSKDVCGGK SCFWISNYNV SSKNGPEIMI KGTTAVEIAS GLHWYIKYWC 180 GAHVSWDKTG SIQIASIPKP GSLPLVKDEG VLIQRPVPWN YYQNVVTSSY SYVWWDWERW 240 EKEIDWMALQ GVNLPLAFNG QEAIWQKVFM DFNISKKDLN GFFGGPAFLA WARMGNLHGW 300 GGPLSQNWLD EQLVLQKQIL CRMLELGMTP VLPSFSGNVP EALKKIFPSA NITRLGEWNT 360 VDNNTRWCCT YLLDASDPLF IQIGKAFIRQ QIKEYGDVTD IYNCDTFNEN SPPTNDPAYI 420 SSLGAAIYKA MSQGDKDSVW LMQGWLFYSD SGFWKPPQMK ALLHSVPFGK MVVLDLFADA 480 KPIWRTSSQF YGTPYIWCML HNFGGNIEMY GILDAVSSGP VDARISKNST MVGVGMCMEG 540 IEQNPVAYEL MSEMAFRSEK VQLVEWLKTY SYRRYGKAVH HVEAAWEILY RTIYNCTDGI 600 ADHNTDFMVN FPDWDPSLNP SSDISKEQHI IQKILTQTGR RKILFQETSS DLPQSHLWYS 660 THEVVNALRL FLDAGNELSK SSTYRYDLVD LTRQVLSKLG NQVYLDAVIA FRQKDAKNFH 720 LHSQKFVQLV KDIDTLLASD DNFLLGTWLE SAKKLAVNPR EMEQYEWNAR TQLTMWFYVT 780 KTNQSKLHDY ANKFWSGLLE NYYLPRASMY FSYLAKALTE NKNFKLEEWR REWISYSNKW 840 QAGKELYPVR AKGDTLAISR ALYEKYFN* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-23 | 108 | 206 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 5.0e-104 | 565 | 866 | 302 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 221 | 560 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 68 | 868 | 5 | 811 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 1 | 868 | 1 | 868 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196873.1 | 0 | 79 | 867 | 16 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 66 | 868 | 1 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 86 | 867 | 24 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 113 | 866 | 175 | 877 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
| PDB | 2vcb_A | 0 | 113 | 866 | 175 | 877 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
| PDB | 2vca_A | 0 | 113 | 866 | 175 | 877 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
| PDB | 2vc9_A | 0 | 113 | 866 | 175 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 113 | 866 | 198 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
