Basic Information | |
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Species | Vitis vinifera |
Cazyme ID | GSVIVT01035950001 |
Family | GH79 |
Protein Properties | Length: 888 Molecular Weight: 96959.3 Isoelectric Point: 6.4093 |
Chromosome | Chromosome/Scaffold: 4 Start: 6370073 End: 6380258 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 36 | 452 | 0 |
DDDFVCATLDWWPPDKCDYGTCSWGRASLLNLDLTNKILFNAIKAFSSLKIRMGGTLQDKVIYQRTGDQQPCAQFVKNSSEMFGFSEGCLPMSRWDELNQ FFRDAGAVVIFGLNALSGRSIGMDGLATGAWNGSDAESLIQYTVNKGYTIHGWELGNELTGNGVGAGVPADQYASDINTLQSMVQKIYASYEAKPLVIGP GGFFDASWYTEFIDKTLKSLQVVTHHIYNLGPGVDDHLIDKILDPSYLDGGSKPFQDLQSILQNSATSATAWVGEAGGAYNSGHNLVTNAFAFSFWYLDQ LGMASSYGNKTYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNVLSTSFNGTKKIRAYSHCSKQSPGITLLLINLDGNTTLRVQVSTENDVASQ RSGGSGNVEEGSVFING | |||
GH79 | 521 | 878 | 0 |
AVVIFGLNALSGRTIGLDGLAAGAWNSSDAESLIRYSANKGYTIHGWELGNELTGNGVGAGVPADQYASDINTLQSMVQKIYAGFEVKPLVLGPGGFFDA SWYTEFIDKTLKSLQVVTHHIYNLGPGVDDHLIDKILDPSYLDGGSKPFQDLQSILQTSATSATAWVGEAGGAYNSGHNLVTNAFAFSFWYLDQLGMASS YDTKTYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNVLSTSFYGTRKIRAYAHCSKQSPGITLLLINLDDKTQRSNFSRMRRVSKIDASVREE YHLTAKDGDLHSQTLLLNGKVLTINSSRIVPPLEPIRVSSMDPVIVAPFSIVFVRFPN |
Full Sequence |
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Protein Sequence Length: 888 Download |
MSQSSIPVAS QRSGGSGNVE EGRVFINGRV AIGSTDDDFV CATLDWWPPD KCDYGTCSWG 60 RASLLNLDLT NKILFNAIKA FSSLKIRMGG TLQDKVIYQR TGDQQPCAQF VKNSSEMFGF 120 SEGCLPMSRW DELNQFFRDA GAVVIFGLNA LSGRSIGMDG LATGAWNGSD AESLIQYTVN 180 KGYTIHGWEL GNELTGNGVG AGVPADQYAS DINTLQSMVQ KIYASYEAKP LVIGPGGFFD 240 ASWYTEFIDK TLKSLQVVTH HIYNLGPGVD DHLIDKILDP SYLDGGSKPF QDLQSILQNS 300 ATSATAWVGE AGGAYNSGHN LVTNAFAFSF WYLDQLGMAS SYGNKTYCRQ TLIGGNYGLL 360 NTTTFVPNPD YYSALLWHRL MGRNVLSTSF NGTKKIRAYS HCSKQSPGIT LLLINLDGNT 420 TLRVQVSTEN DVASQRSGGS GNVEEGSVFI NGRVAIGSTD DDFICATLDW WPPDKCDYGT 480 CSWGRASLLN LDLSNKILLN AIKAFSPLKV RMAEPFNNYW AVVIFGLNAL SGRTIGLDGL 540 AAGAWNSSDA ESLIRYSANK GYTIHGWELG NELTGNGVGA GVPADQYASD INTLQSMVQK 600 IYAGFEVKPL VLGPGGFFDA SWYTEFIDKT LKSLQVVTHH IYNLGPGVDD HLIDKILDPS 660 YLDGGSKPFQ DLQSILQTSA TSATAWVGEA GGAYNSGHNL VTNAFAFSFW YLDQLGMASS 720 YDTKTYCRQT LIGGNYGLLN TTTFVPNPDY YSALLWHRLM GRNVLSTSFY GTRKIRAYAH 780 CSKQSPGITL LLINLDDKTQ RSNFSRMRRV SKIDASVREE YHLTAKDGDL HSQTLLLNGK 840 VLTINSSRIV PPLEPIRVSS MDPVIVAPFS IVFVRFPNIN YPACKYK* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-130 | 449 | 716 | 314 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
pfam03662 | Glyco_hydro_79n | 0 | 20 | 337 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI21126.1 | 0 | 1 | 887 | 1 | 887 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002283254.1 | 0 | 1 | 431 | 17 | 447 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283254.1 | 0 | 432 | 884 | 24 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 1 | 430 | 17 | 446 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 432 | 887 | 24 | 548 | PREDICTED: hypothetical protein [Vitis vinifera] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0001 | 131 | 377 | 122 | 357 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3vo0_A | 0.01 | 613 | 756 | 214 | 357 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3vnz_A | 0.0001 | 131 | 377 | 122 | 357 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3vnz_A | 0.01 | 613 | 756 | 214 | 357 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3vny_A | 0.0001 | 131 | 377 | 122 | 357 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DT548485 | 284 | 77 | 360 | 0 |
DT548485 | 284 | 501 | 739 | 0 |
HO806132 | 318 | 14 | 331 | 0 |
HO806132 | 306 | 449 | 710 | 0 |
DT569595 | 277 | 84 | 360 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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