| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma02g12740.1 |
| Family | GH79 |
| Protein Properties | Length: 519 Molecular Weight: 57410 Isoelectric Point: 8.6128 |
| Chromosome | Chromosome/Scaffold: 02 Start: 11003292 End: 11006437 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 38 | 512 | 0 |
| DDNFICATLDWWPANKCDYDQCPWGQAGILNLDLDNKILTNAVKAFNPLRIRLGGSLEDQIVYQFGKQKKCPHFKKKADGLFGFSQACLPKVRWDEVNDF FNKTGVKLIFGLNALTGKRNSAEDKKNWVGNWNPKNAISLMKYTISKGYKIDSYELGNELCAEGISARVDSVEYAKDITRLRHIVNLLYPIASTRPKVLG PGGFYGKEWFSSFLMNVGPGVVDGITHHIYNLGAGVDKDLINRVQDPYLLSQVAETYKSVAQAVKEFTPWAGPWVGESGGAYNSGGKDVSNTFVNGFWYL DQLGMTSTLNHKVYCRQSLIGGNYGLLNTTTFIPNPDYYGALLWHRLMGSKVLSVSHEGSPFLRTYAHCSKKGPGITVLLINMSNSTTFNVFLINDMNLY PVLNTVRSVPMKMREEYHLTPRDGNIQSDVVMLNGTPLVLTKSLDIAEMKPKLVDPSSSIKAGPDSIVFVQIKSF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 519 Download |
| MDLKVTLCYV VLLLLFSLSS AEDVKLEVKG VASIANTDDN FICATLDWWP ANKCDYDQCP 60 WGQAGILNLD LDNKILTNAV KAFNPLRIRL GGSLEDQIVY QFGKQKKCPH FKKKADGLFG 120 FSQACLPKVR WDEVNDFFNK TGVKLIFGLN ALTGKRNSAE DKKNWVGNWN PKNAISLMKY 180 TISKGYKIDS YELGNELCAE GISARVDSVE YAKDITRLRH IVNLLYPIAS TRPKVLGPGG 240 FYGKEWFSSF LMNVGPGVVD GITHHIYNLG AGVDKDLINR VQDPYLLSQV AETYKSVAQA 300 VKEFTPWAGP WVGESGGAYN SGGKDVSNTF VNGFWYLDQL GMTSTLNHKV YCRQSLIGGN 360 YGLLNTTTFI PNPDYYGALL WHRLMGSKVL SVSHEGSPFL RTYAHCSKKG PGITVLLINM 420 SNSTTFNVFL INDMNLYPVL NTVRSVPMKM REEYHLTPRD GNIQSDVVML NGTPLVLTKS 480 LDIAEMKPKL VDPSSSIKAG PDSIVFVQIK SFNAPACA* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 5.0e-172 | 21 | 341 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI27258.1 | 0 | 1 | 517 | 3 | 523 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 1 | 517 | 1 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 3 | 518 | 4 | 518 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 21 | 516 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
| RefSeq | XP_002512114.1 | 0.00000000000008 | 51 | 99 | 539 | 587 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00000001 | 88 | 404 | 75 | 383 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
| PDB | 3vnz_A | 0.00000001 | 88 | 404 | 75 | 383 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
| PDB | 3vny_A | 0.00000001 | 88 | 404 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
