Basic Information | |
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Species | Glycine max |
Cazyme ID | Glyma05g00663.1 |
Family | GH79 |
Protein Properties | Length: 548 Molecular Weight: 60912.2 Isoelectric Point: 7.0836 |
Chromosome | Chromosome/Scaffold: 05 Start: 349844 End: 355166 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 39 | 536 | 0 |
DDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEVGSLKSPCHPFQKMKGGLFGFSKGCLQMKRWDELNH FFDETGALVTFGLNALHGRHQISHTVWGGDWDPSNAKDFINYTISKGYKIDSWEFGNELSGKGIGARVGAAQYGKDLIKLKEILRTLYKNSTFKPSLVAP GGFYNKEWFDKLLQVTGPGIVNVLTHHVYNLGPGSDEHLDRKILDPECLSKVESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSVSNTFVNSFWYLD QLGIASRYNTKVYCRQTLIGGNYGLLNTTTFIPNPDYYSALLWHQLMGKTVLAASSDVFSPSLRTYAHCSKSRDGITLLLINLSNQTHFTLTVHDRVPVS NGGNENAKSIHTENSFFSHLKKAFSWIGTKGSDVTFREEYHLTPKDDYLRSQTMLLNGIPLELTNDGEIPTLDPLLNNVHSPIHLAPLSIAFIVFPNF |
Full Sequence |
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Protein Sequence Length: 548 Download |
MGIHLALFLF LAFLRMTLSQ DIEHGSILVD GIQAIAETDD NFICATIDWW PHDKCDYNYC 60 PWGDSSAVNL DLSHPFFAKA IQALKPLRIR VGGSLQDQVL YEVGSLKSPC HPFQKMKGGL 120 FGFSKGCLQM KRWDELNHFF DETGALVTFG LNALHGRHQI SHTVWGGDWD PSNAKDFINY 180 TISKGYKIDS WEFGNELSGK GIGARVGAAQ YGKDLIKLKE ILRTLYKNST FKPSLVAPGG 240 FYNKEWFDKL LQVTGPGIVN VLTHHVYNLG PGSDEHLDRK ILDPECLSKV ESIFSNLSET 300 IQKYGPWSSA WVGEAGGAFN SGGRSVSNTF VNSFWYLDQL GIASRYNTKV YCRQTLIGGN 360 YGLLNTTTFI PNPDYYSALL WHQLMGKTVL AASSDVFSPS LRTYAHCSKS RDGITLLLIN 420 LSNQTHFTLT VHDRVPVSNG GNENAKSIHT ENSFFSHLKK AFSWIGTKGS DVTFREEYHL 480 TPKDDYLRSQ TMLLNGIPLE LTNDGEIPTL DPLLNNVHSP IHLAPLSIAF IVFPNFDAPA 540 CAGLRKP* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 23 | 341 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 1 | 542 | 1 | 513 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196400.2 | 0 | 1 | 542 | 1 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 1 | 542 | 1 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321464.1 | 0 | 1 | 542 | 1 | 541 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514696.1 | 0 | 16 | 542 | 16 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00004 | 134 | 430 | 122 | 409 | A Chain A, Higher-density Crystal Structure Of Potato Endo-1,3-beta-glucanase |
PDB | 3vnz_A | 0.00004 | 134 | 430 | 122 | 409 | A Chain A, Higher-density Crystal Structure Of Potato Endo-1,3-beta-glucanase |
PDB | 3vny_A | 0.00004 | 134 | 430 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |