| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma06g21551.2 |
| Family | GH79 |
| Protein Properties | Length: 548 Molecular Weight: 61193.5 Isoelectric Point: 7.278 |
| Chromosome | Chromosome/Scaffold: 06 Start: 18118210 End: 18123899 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 40 | 536 | 0 |
| DNFICATIDWWPHDKCDYNHCPWGYSSVVNLDLSHPFLAKAIQALKPLRIRLGGSLQDRVLYDVGSLKSPCHPLQSVKGELFGFSKGCLHMKRWDELNQF FNETGAIVTFGLNLLHGKHQISHNVWEGAWDPTNAYNFIEYTISKGYKIDSWELGNELSGKGIGASVGVAQYGKDLIKLKQILSTLYENSNFKPSLVAPG GFYEKHWYDRLLQVSGSGIINVLTHHIYNLGPGSDEHLERKILDPERLSRVESIFSNLSETIQKYGPWCSAWVGEAGGAYNSGGNDVSNRFLNSFWYLDQ LGMASSYSTKVYCRQTLIGGNYGLLNTTTFAPNPDYYSALLWHQLMGKKVLAVSSDVSSPFLRTYAHCAKDRAGVTLLLINLSNQTDFILTVRNPVTASV VENEVATGTHKESSFFDKLKKTFSWVGTKGSEVTFREEYHLTPKDGYLRSQTMVLNGIPLELTDEGDLPRLDPVRNNLRSPIYMTPLSIAFVVYPNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 548 Download |
| MRFRIALFLF LASLQATLSQ DIEHGSLLVD GAQTKAETGD NFICATIDWW PHDKCDYNHC 60 PWGYSSVVNL DLSHPFLAKA IQALKPLRIR LGGSLQDRVL YDVGSLKSPC HPLQSVKGEL 120 FGFSKGCLHM KRWDELNQFF NETGAIVTFG LNLLHGKHQI SHNVWEGAWD PTNAYNFIEY 180 TISKGYKIDS WELGNELSGK GIGASVGVAQ YGKDLIKLKQ ILSTLYENSN FKPSLVAPGG 240 FYEKHWYDRL LQVSGSGIIN VLTHHIYNLG PGSDEHLERK ILDPERLSRV ESIFSNLSET 300 IQKYGPWCSA WVGEAGGAYN SGGNDVSNRF LNSFWYLDQL GMASSYSTKV YCRQTLIGGN 360 YGLLNTTTFA PNPDYYSALL WHQLMGKKVL AVSSDVSSPF LRTYAHCAKD RAGVTLLLIN 420 LSNQTDFILT VRNPVTASVV ENEVATGTHK ESSFFDKLKK TFSWVGTKGS EVTFREEYHL 480 TPKDGYLRSQ TMVLNGIPLE LTDEGDLPRL DPVRNNLRSP IYMTPLSIAF VVYPNFDAPA 540 CATHRKL* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 23 | 341 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15157.1 | 0 | 12 | 542 | 12 | 513 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196400.2 | 0 | 1 | 542 | 1 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | XP_002284470.1 | 0 | 12 | 542 | 12 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 542 | 1 | 541 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 18 | 542 | 18 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.001 | 134 | 478 | 122 | 452 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.001 | 134 | 478 | 122 | 452 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.001 | 134 | 478 | 122 | 452 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
