| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma09g11990.1 |
| Family | GH79 |
| Protein Properties | Length: 539 Molecular Weight: 59125 Isoelectric Point: 6.4566 |
| Chromosome | Chromosome/Scaffold: 09 Start: 12301028 End: 12305650 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 51 | 532 | 0 |
| DEDFVCATLDWWPPEKCDYGRCSWGLASLLNLDLNNKIFLNAVKAFSPLKLRLGGSLQDKLIYGTEDNHQPCTPFVKNPSEMFSFTQGCLPMDRWDELNY FFEKAGAKIIFGLNALAGKSIHGGSAKGPWNYTNAESFIRYTVRNGYTIYGWELGNELSGNGVGTSITAEQYALDVAALHDVVYNAYKKIEPKPLVIAPG GFYDANWFNKFISKSGKSIDVVTHHIYNLGPGVDEHLVERILDPSYLDKEVSTFSGLKNILAGTGTSATAWVGESGGAYNSGHHLVSDAFVYSFWYLDQL GMSAAYDTKTYCRQTLIGGNYGLLNTTNFLPNPDYYSALLWHRLMGRHVLSTTFSGTNKIRAYAHCAKQSKGITVLLINLDSNTTVEAEVTFNNAAKSLR HRKMSTHSKVMELPLASETAREEYHLTPQDGDIHSQIMVLNGNPLSVSSDGDIPPLEPINVNSSEPIRVAPFSIVFAHLPDA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 539 Download |
| MGSRIQLLPI CFWLHLTCFS FFFGSIVSVR GDATVQGSVA IDGKAVIGTI DEDFVCATLD 60 WWPPEKCDYG RCSWGLASLL NLDLNNKIFL NAVKAFSPLK LRLGGSLQDK LIYGTEDNHQ 120 PCTPFVKNPS EMFSFTQGCL PMDRWDELNY FFEKAGAKII FGLNALAGKS IHGGSAKGPW 180 NYTNAESFIR YTVRNGYTIY GWELGNELSG NGVGTSITAE QYALDVAALH DVVYNAYKKI 240 EPKPLVIAPG GFYDANWFNK FISKSGKSID VVTHHIYNLG PGVDEHLVER ILDPSYLDKE 300 VSTFSGLKNI LAGTGTSATA WVGESGGAYN SGHHLVSDAF VYSFWYLDQL GMSAAYDTKT 360 YCRQTLIGGN YGLLNTTNFL PNPDYYSALL WHRLMGRHVL STTFSGTNKI RAYAHCAKQS 420 KGITVLLINL DSNTTVEAEV TFNNAAKSLR HRKMSTHSKV MELPLASETA REEYHLTPQD 480 GDIHSQIMVL NGNPLSVSSD GDIPPLEPIN VNSSEPIRVA PFSIVFAHLP DAVVSACG* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 35 | 351 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU20377.1 | 0 | 1 | 537 | 1 | 524 | unknown [Glycine max] |
| EMBL | CAN81917.1 | 0 | 1 | 537 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 537 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 537 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002533671.1 | 0 | 1 | 530 | 1 | 544 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00000000006 | 146 | 436 | 122 | 406 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3vnz_A | 0.00000000006 | 146 | 436 | 122 | 406 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3vny_A | 0.00000000006 | 146 | 436 | 122 | 406 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
