| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma15g23550.1 |
| Family | GH79 |
| Protein Properties | Length: 539 Molecular Weight: 59152.9 Isoelectric Point: 6.0477 |
| Chromosome | Chromosome/Scaffold: 15 Start: 23032798 End: 23037496 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 51 | 532 | 0 |
| DDDFVCATLDWWPPEKCDYGRCSWGLASLLNLDLNNKIFLNAVKAFSPLKLRLGGSLQDKVIYGTEDNHQPCTPFVKNPSEMFGFTQGCLPMDRWDELNY FFEKAGAKIIFGLNALAGKSIHSGSAKGPWNYTNAESFIRYTVGNGYSIYGWELGNELSGSGVGTSITADQYALDVAALHDVVYNAYEKTEPKPLVIAPG GFFDANWFNIFISKSGKSIDVVTHHIYNLGPGVDEHLVERILDPSYLDKEASTFSGLKNILASTGTSATAWVGESGGAYNSGHHLVSDAFVYSFWYLDQL GMSAAYDTKTYCRQSLIGGNYGLLNTTNFLPNPDYYSALLWHRLMGRHVLSTTFSGTNKIRAYAHCAKQSKGITVLLINLDSNTTVEAEVTFNNNAESLR HRKMSSHSKRMELPLASETAREEYHLTPQDGDIHSQTMVLNGKALSVNSDGDIPPLEPIYVNSSEPIRVAAFSIVFAHLPDA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 539 Download |
| MSSRIRLLGI CLWLHLTCFT FIFGNIVSVR GDATLQGTVA IDDKVVIGTI DDDFVCATLD 60 WWPPEKCDYG RCSWGLASLL NLDLNNKIFL NAVKAFSPLK LRLGGSLQDK VIYGTEDNHQ 120 PCTPFVKNPS EMFGFTQGCL PMDRWDELNY FFEKAGAKII FGLNALAGKS IHSGSAKGPW 180 NYTNAESFIR YTVGNGYSIY GWELGNELSG SGVGTSITAD QYALDVAALH DVVYNAYEKT 240 EPKPLVIAPG GFFDANWFNI FISKSGKSID VVTHHIYNLG PGVDEHLVER ILDPSYLDKE 300 ASTFSGLKNI LASTGTSATA WVGESGGAYN SGHHLVSDAF VYSFWYLDQL GMSAAYDTKT 360 YCRQSLIGGN YGLLNTTNFL PNPDYYSALL WHRLMGRHVL STTFSGTNKI RAYAHCAKQS 420 KGITVLLINL DSNTTVEAEV TFNNNAESLR HRKMSSHSKR MELPLASETA REEYHLTPQD 480 GDIHSQTMVL NGKALSVNSD GDIPPLEPIY VNSSEPIRVA AFSIVFAHLP DAVVSACC* 540 |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 0 | 37 | 351 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU20377.1 | 0 | 1 | 537 | 1 | 524 | unknown [Glycine max] |
| EMBL | CAN81917.1 | 0 | 1 | 537 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 537 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 537 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002533671.1 | 0 | 1 | 530 | 1 | 544 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000000004 | 146 | 469 | 122 | 429 | A Chain A, Pectin Methylesterase From Carrot |
| PDB | 3vnz_A | 0.0000000004 | 146 | 469 | 122 | 429 | A Chain A, Pectin Methylesterase From Carrot |
| PDB | 3vny_A | 0.0000000004 | 146 | 469 | 122 | 429 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
