| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma17g08444.1 |
| Family | GH79 |
| Protein Properties | Length: 548 Molecular Weight: 60873 Isoelectric Point: 6.9538 |
| Chromosome | Chromosome/Scaffold: 17 Start: 6247117 End: 6252069 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 39 | 536 | 0 |
| DDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEVGSLKSPCHPFQKMKGGLFGFSKGCLQMKRWDELNH FFDETGALVTFGLNALRGRHQISHTVWGGDWDPSNAKDFISYTISKGYKIDSWEFGNELSGKGIGASVGAAQYGKDLIKLKEILHTLYKNSTFKPSLVAP GGFYNKEWFDKLLQVTGPGIVNVLTHHVYNLGPGSDEHLDRKILDPENLSKIESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSISNTFVNSFWYLD QLGIASRYNTKVYCRQTLIGGNYGLLNTTTFIPNPDYYSALLWRQLMGKTVLAASSDVFSPSLRTYAHCSKGRDGITLLLINLSNQTHFTLTVHDRVPVS NGGNENAKSIHTENSFFSHLKRAFSWIGTKGSDVTFREEYQLTPKDDYLRSQTMLLNGIPLELTNDGEIPTLDPLLNNVHSPIHLAPLSIAFIVFPNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 548 Download |
| MGIHLGLFLF LASLRMTLSQ DVEHGSVLVD GIQAIAETDD NFICATIDWW PHDKCDYNYC 60 PWGDSSAVNL DLSHPFFAKA IQALKPLRIR VGGSLQDQVL YEVGSLKSPC HPFQKMKGGL 120 FGFSKGCLQM KRWDELNHFF DETGALVTFG LNALRGRHQI SHTVWGGDWD PSNAKDFISY 180 TISKGYKIDS WEFGNELSGK GIGASVGAAQ YGKDLIKLKE ILHTLYKNST FKPSLVAPGG 240 FYNKEWFDKL LQVTGPGIVN VLTHHVYNLG PGSDEHLDRK ILDPENLSKI ESIFSNLSET 300 IQKYGPWSSA WVGEAGGAFN SGGRSISNTF VNSFWYLDQL GIASRYNTKV YCRQTLIGGN 360 YGLLNTTTFI PNPDYYSALL WRQLMGKTVL AASSDVFSPS LRTYAHCSKG RDGITLLLIN 420 LSNQTHFTLT VHDRVPVSNG GNENAKSIHT ENSFFSHLKR AFSWIGTKGS DVTFREEYQL 480 TPKDDYLRSQ TMLLNGIPLE LTNDGEIPTL DPLLNNVHSP IHLAPLSIAF IVFPNFDAPA 540 CAEHRKL* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 23 | 341 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15157.1 | 0 | 1 | 542 | 1 | 513 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196400.2 | 0 | 3 | 542 | 10 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | XP_002284470.1 | 0 | 1 | 542 | 1 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 542 | 1 | 541 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 16 | 542 | 16 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00001 | 134 | 430 | 122 | 409 | A Chain A, Crystal Structure Of Nxg1-Deltayniig In Complex With Xllg, A Xyloglucan Derived Oligosaccharide |
| PDB | 3vnz_A | 0.00001 | 134 | 430 | 122 | 409 | A Chain A, Crystal Structure Of Nxg1-Deltayniig In Complex With Xllg, A Xyloglucan Derived Oligosaccharide |
| PDB | 3vny_A | 0.00001 | 134 | 430 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
