| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma17g11670.1 |
| Family | GH79 |
| Protein Properties | Length: 526 Molecular Weight: 57881.3 Isoelectric Point: 8.2725 |
| Chromosome | Chromosome/Scaffold: 17 Start: 8751903 End: 8755597 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 53 | 519 | 0 |
| DSICATLDWWPSQKCDYGKCSWGHASLLNLDLNNKILLNAVKAFSPLKIRLGGTLQDKVIYGTEDCRQPCTPFVLNANEMFGFTQGCLPMYRWDELNSFF QKAGVKVVFGLNALAGKSIKSGSAVGPWNYTNAESLIRYTVRKKYTIHGWELGNELCGNGIGASVAADQYAFDVGALRNIVENAYRGFEHNKPLVIAPGG FFDSDWFKEFISKSGKSVDVVTHHIYNLGPGVDDHITEKILDPSYLDGEANTFSSLKSIVQSSATSVKSWVGEAGGAYNSGHHLVSDAFVYSFWYLDQLG MSAVYDTRTYCRQSLIGGNYGLLNTSTFMPNPDYYSALLWHRLMGGRVLSTTFYGTKKIRTYAHCAKQSKGITILVLNLDNSTTVEVNVALKFNKLPYRR VGEPARREYHLTAPDRNLHSQTMLLNGKILSVNSAGEIPPLDPLYVNSRKPIIVGPLSIVFAHIPNV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 526 Download |
| MGSQIRLLGL CLWMYLACLS FIGVGAVYGR EGEVLEGIVL VHGKTAIGRI DDDSICATLD 60 WWPSQKCDYG KCSWGHASLL NLDLNNKILL NAVKAFSPLK IRLGGTLQDK VIYGTEDCRQ 120 PCTPFVLNAN EMFGFTQGCL PMYRWDELNS FFQKAGVKVV FGLNALAGKS IKSGSAVGPW 180 NYTNAESLIR YTVRKKYTIH GWELGNELCG NGIGASVAAD QYAFDVGALR NIVENAYRGF 240 EHNKPLVIAP GGFFDSDWFK EFISKSGKSV DVVTHHIYNL GPGVDDHITE KILDPSYLDG 300 EANTFSSLKS IVQSSATSVK SWVGEAGGAY NSGHHLVSDA FVYSFWYLDQ LGMSAVYDTR 360 TYCRQSLIGG NYGLLNTSTF MPNPDYYSAL LWHRLMGGRV LSTTFYGTKK IRTYAHCAKQ 420 SKGITILVLN LDNSTTVEVN VALKFNKLPY RRVGEPARRE YHLTAPDRNL HSQTMLLNGK 480 ILSVNSAGEI PPLDPLYVNS RKPIIVGPLS IVFAHIPNVL LSACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 36 | 352 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU20377.1 | 0 | 1 | 525 | 1 | 525 | unknown [Glycine max] |
| EMBL | CAN81917.1 | 0 | 1 | 524 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 524 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 524 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 37 | 525 | 1 | 506 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000001 | 146 | 440 | 122 | 409 | A Chain A, Crystal Structure Of The Nasturtium Seedling Mutant Xyloglucanase Isoform Nxg1-Delta-Yniig |
| PDB | 3vnz_A | 0.0000001 | 146 | 440 | 122 | 409 | A Chain A, Crystal Structure Of The Nasturtium Seedling Mutant Xyloglucanase Isoform Nxg1-Delta-Yniig |
| PDB | 3vny_A | 0.0000001 | 146 | 440 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
