Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.004G108900.2 |
Family | GH79 |
Protein Properties | Length: 547 Molecular Weight: 60246.5 Isoelectric Point: 7.3995 |
Chromosome | Chromosome/Scaffold: 04 Start: 22508569 End: 22511521 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 45 | 536 | 0 |
DDDFICATLDWWPPEKCDYGTCSWGLAGLLNLDLNKNLFLNAVKAFSPLKIRLGGTLQDKVIYDSDDNQLPCTSFVKNTSEMFGFTQGCLPMNRWDDLNS FFQKAGAKVIFGLNALAGRTIASDGSAVGAWNYTNAESFMQYTVDKNYTIHGWELGNELCGSGVGTRVSADQYAADTAALQSIVQKIYQNVDLKPLIITP GGFYDSDWFTEYIDKTNKSLDVVTHHIYNLGPGVDDHLVEKILDPSILEGVSGTFSGLHNIIKNSTTSAAAWVGEAGGAYNSGHNLVTNAFVFSFWYLDQ LGMASKYDTKTYCRQSLVGGNYGLLNTTNFEPNPDYYSALLWHRLMGRNVLSTSFTGTDKIRSYTHCAKQSKGITLLLINLNNSTTVQAKLAFNSTMSLR HKHRSRISHNKHRIHKTTIIKLPQGIDGKIRREEYHLTAKDGNLQSQSMLLNGNILSVSSSGIIPHLEPLHVKSAKPIMVAPLSIVFTHMPD |
Full Sequence |
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Protein Sequence Length: 547 Download |
MGFCFWVCFI SLLNFYSLSF VSSQADASAE GTVFIDGKAP IGRIDDDFIC ATLDWWPPEK 60 CDYGTCSWGL AGLLNLDLNK NLFLNAVKAF SPLKIRLGGT LQDKVIYDSD DNQLPCTSFV 120 KNTSEMFGFT QGCLPMNRWD DLNSFFQKAG AKVIFGLNAL AGRTIASDGS AVGAWNYTNA 180 ESFMQYTVDK NYTIHGWELG NELCGSGVGT RVSADQYAAD TAALQSIVQK IYQNVDLKPL 240 IITPGGFYDS DWFTEYIDKT NKSLDVVTHH IYNLGPGVDD HLVEKILDPS ILEGVSGTFS 300 GLHNIIKNST TSAAAWVGEA GGAYNSGHNL VTNAFVFSFW YLDQLGMASK YDTKTYCRQS 360 LVGGNYGLLN TTNFEPNPDY YSALLWHRLM GRNVLSTSFT GTDKIRSYTH CAKQSKGITL 420 LLINLNNSTT VQAKLAFNST MSLRHKHRSR ISHNKHRIHK TTIIKLPQGI DGKIRREEYH 480 LTAKDGNLQS QSMLLNGNIL SVSSSGIIPH LEPLHVKSAK PIMVAPLSIV FTHMPDVTVP 540 ACKVQP* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd01538 | PBP1_ABC_xylose_binding | 0.008 | 140 | 228 | 100 | + Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. | ||
pfam03662 | Glyco_hydro_79n | 0 | 29 | 346 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN81917.1 | 0 | 1 | 544 | 8 | 556 | hypothetical protein [Vitis vinifera] |
EMBL | CBI25561.1 | 0 | 1 | 543 | 1 | 533 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 543 | 12 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324603.1 | 0 | 31 | 542 | 1 | 505 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533671.1 | 0 | 2 | 543 | 9 | 551 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000002 | 140 | 400 | 122 | 371 | A Chain A, Atg8 Transfer From Atg7 To Atg3: A Distinctive E1-E2 Architecture And Mechanism In The Autophagy Path |
PDB | 3vnz_A | 0.000002 | 140 | 400 | 122 | 371 | A Chain A, Atg8 Transfer From Atg7 To Atg3: A Distinctive E1-E2 Architecture And Mechanism In The Autophagy Path |
PDB | 3vny_A | 0.000002 | 140 | 400 | 122 | 371 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |