| Basic Information | |
|---|---|
| Species | Gossypium raimondii |
| Cazyme ID | Gorai.004G170700.1 |
| Family | GH89 |
| Protein Properties | Length: 821 Molecular Weight: 93271.1 Isoelectric Point: 7.7862 |
| Chromosome | Chromosome/Scaffold: 04 Start: 47025514 End: 47033037 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 108 | 816 | 0 |
| GPEILIKGTTAVEIASGLHWYIKYFCGAHVSWDKTGGVQLASVPKPGSLPLVKDGGVLIQRPVPWNYYQNVVTSSYSYVWWDWERWEKEIDWMALQGINL PLAFSGQEAIWQKVFMGFNISMEDLNDFFGGPAFLAWARMGNLHTWGGPLSKNWLKQQLVLQKKILSRMVELGMTPVLPSFSGNVPAALKTIFPTANITR LGDWNTVDGDPHWCCTYLLNPSDPLFVEIGEAFIKMQIKEYGDVTDIYNCDTFNENSPPTNDTIYISSLGAAVYKAMSNGDKDAVWLMQGWLFYSDSTFW KPPQMKALLHSVPVGKMIVLDLFADVKPIWATSSQFYGTPYVWCLLHNFGGNIEMYGTLDAISSGPVDARISKNSTMVGVGMCMEGIEQNPVVYELMSEM AFRKEKVQVLEWLKTYTHRRYGKSVQQIKEAWAILYHTVYNCTDGIADHNIDFIVKFPDWDPSINFGSRPSKLNSMHTFRLRTRSRRFSFQERSSDLPQA HLWYSTHEVVSALKLFLAAGNDLAGSLTYRYDLVDLTRQVLSKLANQVYLDAINAFRRKDVKALNIHSQKFIQLIKDIDVLLASDDNFLLGTWLESAKLL AENPSEMRQYEWNARTQVTMWFDTTPTNQSKLHDYANKFWSGLLEGYYLPRASSYFSYLSKSLEKNESFKLVEWRKQWVSFSNKWQAGLELYPVKAQGNF LTIAKALFD | |||
| Full Sequence |
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| Protein Sequence Length: 821 Download |
| MAVAIIRILN NSPTMKFIIG DVLIIIFILF ITRLPQSFST TEAIQPSLTR LDSKRSSPSV 60 QESAAKAVLG RLLPTHLLSF HFKIVSKDVC GGQGCFLIEN YDGPTENGPE ILIKGTTAVE 120 IASGLHWYIK YFCGAHVSWD KTGGVQLASV PKPGSLPLVK DGGVLIQRPV PWNYYQNVVT 180 SSYSYVWWDW ERWEKEIDWM ALQGINLPLA FSGQEAIWQK VFMGFNISME DLNDFFGGPA 240 FLAWARMGNL HTWGGPLSKN WLKQQLVLQK KILSRMVELG MTPVLPSFSG NVPAALKTIF 300 PTANITRLGD WNTVDGDPHW CCTYLLNPSD PLFVEIGEAF IKMQIKEYGD VTDIYNCDTF 360 NENSPPTNDT IYISSLGAAV YKAMSNGDKD AVWLMQGWLF YSDSTFWKPP QMKALLHSVP 420 VGKMIVLDLF ADVKPIWATS SQFYGTPYVW CLLHNFGGNI EMYGTLDAIS SGPVDARISK 480 NSTMVGVGMC MEGIEQNPVV YELMSEMAFR KEKVQVLEWL KTYTHRRYGK SVQQIKEAWA 540 ILYHTVYNCT DGIADHNIDF IVKFPDWDPS INFGSRPSKL NSMHTFRLRT RSRRFSFQER 600 SSDLPQAHLW YSTHEVVSAL KLFLAAGNDL AGSLTYRYDL VDLTRQVLSK LANQVYLDAI 660 NAFRRKDVKA LNIHSQKFIQ LIKDIDVLLA SDDNFLLGTW LESAKLLAEN PSEMRQYEWN 720 ARTQVTMWFD TTPTNQSKLH DYANKFWSGL LEGYYLPRAS SYFSYLSKSL EKNESFKLVE 780 WRKQWVSFSN KWQAGLELYP VKAQGNFLTI AKALFDKYLS * |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-22 | 61 | 159 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-104 | 518 | 818 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 3.0e-179 | 174 | 513 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 4 | 820 | 53 | 868 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 56 | 820 | 51 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 48 | 819 | 32 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 23 | 820 | 4 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 37 | 819 | 22 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 66 | 818 | 175 | 877 | A Chain A, 1.15 Angstrom Crystal Structure Of The Ma3 Domain Of Pdcd4 |
| PDB | 2vcb_A | 0 | 66 | 818 | 175 | 877 | A Chain A, 1.15 Angstrom Crystal Structure Of The Ma3 Domain Of Pdcd4 |
| PDB | 2vca_A | 0 | 66 | 818 | 175 | 877 | A Chain A, 1.15 Angstrom Crystal Structure Of The Ma3 Domain Of Pdcd4 |
| PDB | 2vc9_A | 0 | 66 | 818 | 175 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 66 | 818 | 198 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
