Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.006G004400.1 |
Family | GH79 |
Protein Properties | Length: 497 Molecular Weight: 55146.6 Isoelectric Point: 6.5834 |
Chromosome | Chromosome/Scaffold: 06 Start: 893459 End: 895884 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 37 | 490 | 0 |
TDDNFDLKKKVLINAIKAFNSLRIKVGGSLQDQVVYGVGEVKNCPNFMKKEGSLFGFSQGCLPVERWDELNNFFNQTGWVTFGLNALLGRNESQSENGLW VGDWNSQNARDFMKYTISRGYKVDSYEFGNQLSGAGMGARVEAEQYGKDVIVLKNMVKELHPDPKTQPKVLGPSGFYDEKWFNSFLEVLGQEVVDGVTHH IYNLGPGDDLNLITKIQDPSCLNQVAQTYRGVFNIVNKFKPQSGAWVSESGGALQGGAKDVSPTFADGFWYFDQLGMASTYNHKVFCRQTLIGGNYALLD TTTFIPNPDYYGALLWHRLMGSIVLAVTQESNPNLRVYAHCAKKKPGISIIFINLSNDSTFDVTLSSYEHRRRNLRPTDAAKPNFEFTSHLNREEYHLTA LGGNIQGQIVLLNDVPMVLTDTFDIPAMDPKLVNASTPISVAAHSIVYVTIRDF |
Full Sequence |
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Protein Sequence Length: 497 Download |
MDLKCIFSLV IIVSRISLSF TQNVNVVIQG STSVAETDDN FDLKKKVLIN AIKAFNSLRI 60 KVGGSLQDQV VYGVGEVKNC PNFMKKEGSL FGFSQGCLPV ERWDELNNFF NQTGWVTFGL 120 NALLGRNESQ SENGLWVGDW NSQNARDFMK YTISRGYKVD SYEFGNQLSG AGMGARVEAE 180 QYGKDVIVLK NMVKELHPDP KTQPKVLGPS GFYDEKWFNS FLEVLGQEVV DGVTHHIYNL 240 GPGDDLNLIT KIQDPSCLNQ VAQTYRGVFN IVNKFKPQSG AWVSESGGAL QGGAKDVSPT 300 FADGFWYFDQ LGMASTYNHK VFCRQTLIGG NYALLDTTTF IPNPDYYGAL LWHRLMGSIV 360 LAVTQESNPN LRVYAHCAKK KPGISIIFIN LSNDSTFDVT LSSYEHRRRN LRPTDAAKPN 420 FEFTSHLNRE EYHLTALGGN IQGQIVLLND VPMVLTDTFD IPAMDPKLVN ASTPISVAAH 480 SIVYVTIRDF HAPVCV* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 3.0e-133 | 22 | 312 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 20 | 496 | 23 | 524 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 20 | 496 | 21 | 522 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 17 | 496 | 19 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 24 | 494 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.001 | 41 | 71 | 557 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0003 | 101 | 375 | 119 | 383 | A Chain A, Trehalose-6-Phosphate From E. Coli Bound With Udp-Glucose. |
PDB | 3vnz_A | 0.0003 | 101 | 375 | 119 | 383 | A Chain A, Trehalose-6-Phosphate From E. Coli Bound With Udp-Glucose. |
PDB | 3vny_A | 0.0003 | 101 | 375 | 119 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |