| Basic Information | |
|---|---|
| Species | Gossypium raimondii |
| Cazyme ID | Gorai.006G267500.1 |
| Family | GH79 |
| Protein Properties | Length: 543 Molecular Weight: 60492.9 Isoelectric Point: 9.0029 |
| Chromosome | Chromosome/Scaffold: 06 Start: 50580257 End: 50586800 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 39 | 536 | 0 |
| DDNFVCATIDWWPHDKCDYKQCPWHYTSAITLDLSHPILTKAIQAFNRLRIRIGGSLQDQVLYNVGNLKSPCHPFRKMKHGLFGFSKGCLQMKRWDELNH FFNATSVMLTFGLNALYGRHKIKGSLWGGEWDSSNAQDFIKYSFSKGYQIDSWEYGNELSGNGVGAHVHADRYGKDLIHLKKIIKELYRGSQFEPSLVAP GGFFNQQWFTKLLQVSGSNVLDAISHHIYNLGAGSDPKLVSKILDPNHLNKVANTFINLARTVQTHGPWSSAWVGESGGAYNSGGPHVSDTFVNSFWYLD QLGMASKYHTKVYCRQTLIGGNYGLLNATTYVPNPDYYSALLWHRLMGKVVLAVGSDASPFLRSYAHCSKGRIGVTLLVINLSDQTKFITDVQNSMNNNI RLATEQQNISRKSFSRSLKNTASGAEIKASSDEYSYREEYHLTPKNGYLQTRTMVLNGIPLELTSTGNIPRLDPVRVNVKSPISITPLSIAFLVFPDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 543 Download |
| MEFGMILIVF VASIPTILAE DISYGTIVVD GTTSIAQTDD NFVCATIDWW PHDKCDYKQC 60 PWHYTSAITL DLSHPILTKA IQAFNRLRIR IGGSLQDQVL YNVGNLKSPC HPFRKMKHGL 120 FGFSKGCLQM KRWDELNHFF NATSVMLTFG LNALYGRHKI KGSLWGGEWD SSNAQDFIKY 180 SFSKGYQIDS WEYGNELSGN GVGAHVHADR YGKDLIHLKK IIKELYRGSQ FEPSLVAPGG 240 FFNQQWFTKL LQVSGSNVLD AISHHIYNLG AGSDPKLVSK ILDPNHLNKV ANTFINLART 300 VQTHGPWSSA WVGESGGAYN SGGPHVSDTF VNSFWYLDQL GMASKYHTKV YCRQTLIGGN 360 YGLLNATTYV PNPDYYSALL WHRLMGKVVL AVGSDASPFL RSYAHCSKGR IGVTLLVINL 420 SDQTKFITDV QNSMNNNIRL ATEQQNISRK SFSRSLKNTA SGAEIKASSD EYSYREEYHL 480 TPKNGYLQTR TMVLNGIPLE LTSTGNIPRL DPVRVNVKSP ISITPLSIAF LVFPDFVAPA 540 CR* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 341 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15157.1 | 0 | 12 | 541 | 12 | 512 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196400.2 | 0 | 6 | 541 | 7 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | XP_002284470.1 | 0 | 12 | 541 | 12 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 541 | 1 | 540 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 15 | 541 | 15 | 538 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 89 | 446 | 75 | 427 | A Chain A, Crystal Structure Of 8-amino-7-oxononanoate Synthase (biof) From Francisella Tularensis |
| PDB | 3vnz_A | 0.0002 | 89 | 446 | 75 | 427 | A Chain A, Crystal Structure Of 8-amino-7-oxononanoate Synthase (biof) From Francisella Tularensis |
| PDB | 3vny_A | 0.0002 | 89 | 446 | 75 | 427 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 4atw_F | 0.004 | 167 | 274 | 143 | 241 | A Chain A, The Crystal Structure Of Arabinofuranosidase |
| PDB | 4atw_E | 0.004 | 167 | 274 | 143 | 241 | A Chain A, The Crystal Structure Of Arabinofuranosidase |
