Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.009G305800.1 |
Family | GH79 |
Protein Properties | Length: 525 Molecular Weight: 59091.7 Isoelectric Point: 8.2911 |
Chromosome | Chromosome/Scaffold: 09 Start: 27739797 End: 27742037 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 38 | 518 | 0 |
DEDFICVTLDCGLQTNVITINARGIFINFYYIFHLWDLKNKILEKAVKAFHPLRIRVGGSLQDQVVYNVRNNIENCQPFQKQDKGFLFGFSIGCLDMKRW DELNKFFNQTRAKVTFGLNALIGRKESETEKTLWVGDWYSHNARDLMNYTISKGYKIDSYELGNELCGSGVSNKIGAKQYAKDMATLKNLVKEMYPNPKT QPKILGPGGFYDKKWFDTFLDASGHDVIDGVTHHIYNLGPGNNPDVVRRVQDPFFLTQIAQTFKDVSNAIDKFAPWSGAWVSESGGAYNSGGQLVSYTFA FGFWYLDQLGMTSVYNHKVYCRQALIGGNYALLNTTTFVPNPDYYGALLWHKVMGSKVLSVTHKGSPYLRVYSHCSKKEPGVSFVFINLSKNTSFEIDLF HDLNLNGGSPNFEFKGHKEREEYHLTPKDGNILSSVVLLNGTPLELLDSMEILELKPKLVDGLKRINIAAHSIAFVTIRDF |
Full Sequence |
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Protein Sequence Length: 525 Download |
MNFRSIMFFV VLLSCLLVSK AEKVEVVVVG ATSIAQTDED FICVTLDCGL QTNVITINAR 60 GIFINFYYIF HLWDLKNKIL EKAVKAFHPL RIRVGGSLQD QVVYNVRNNI ENCQPFQKQD 120 KGFLFGFSIG CLDMKRWDEL NKFFNQTRAK VTFGLNALIG RKESETEKTL WVGDWYSHNA 180 RDLMNYTISK GYKIDSYELG NELCGSGVSN KIGAKQYAKD MATLKNLVKE MYPNPKTQPK 240 ILGPGGFYDK KWFDTFLDAS GHDVIDGVTH HIYNLGPGNN PDVVRRVQDP FFLTQIAQTF 300 KDVSNAIDKF APWSGAWVSE SGGAYNSGGQ LVSYTFAFGF WYLDQLGMTS VYNHKVYCRQ 360 ALIGGNYALL NTTTFVPNPD YYGALLWHKV MGSKVLSVTH KGSPYLRVYS HCSKKEPGVS 420 FVFINLSKNT SFEIDLFHDL NLNGGSPNFE FKGHKEREEY HLTPKDGNIL SSVVLLNGTP 480 LELLDSMEIL ELKPKLVDGL KRINIAAHSI AFVTIRDFNA PACF* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
COG2369 | COG2369 | 0.002 | 155 | 262 | 113 | + Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown] | ||
pfam03662 | Glyco_hydro_79n | 1.0e-147 | 30 | 347 | 331 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 524 | 3 | 524 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 524 | 1 | 522 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 21 | 523 | 23 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 21 | 522 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00009 | 74 | 103 | 558 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000002 | 138 | 410 | 122 | 383 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
PDB | 3vnz_A | 0.0000002 | 138 | 410 | 122 | 383 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
PDB | 3vny_A | 0.0000002 | 138 | 410 | 122 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |