Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.011G050000.1 |
Family | GT65 |
Protein Properties | Length: 434 Molecular Weight: 49015.9 Isoelectric Point: 8.934 |
Chromosome | Chromosome/Scaffold: 11 Start: 3898177 End: 3899514 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT65 | 76 | 374 | 0 |
IAFVRACLTTRMLNRTLLMPSLSASLFCKKINRLQPISFDKVFKFERFNTLCEGFVQLARYSDLKNRTGVYDLRKGSGRKWTVERDLEQLKQSIINGPID MHEVIRMVGKNPFLWHGHWPVKDYARVFECLVLVDEISKEADKVVSKIRQIGRKLRSEPGMGSSLRPAPYVAVHIRVEIDWMIHCKKLEQRSGVSQICSS KQEIIERVGKIINLEAPIVVYLAVADNLLNDSSLLSGWNKGLVPCEKKNLGVDGIYKKHPYLIQSAIDNEVCSKADIFVGNSFSTFSSHIVFERTQKMM |
Full Sequence |
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Protein Sequence Length: 434 Download |
MDLSSNCKLS RLFACNLTSI ICKCLALVTI ALFFRAILYH LSSGDVLERD DLDLIPGRSM 60 LSQSDEGIRR NKFLEIAFVR ACLTTRMLNR TLLMPSLSAS LFCKKINRLQ PISFDKVFKF 120 ERFNTLCEGF VQLARYSDLK NRTGVYDLRK GSGRKWTVER DLEQLKQSII NGPIDMHEVI 180 RMVGKNPFLW HGHWPVKDYA RVFECLVLVD EISKEADKVV SKIRQIGRKL RSEPGMGSSL 240 RPAPYVAVHI RVEIDWMIHC KKLEQRSGVS QICSSKQEII ERVGKIINLE APIVVYLAVA 300 DNLLNDSSLL SGWNKGLVPC EKKNLGVDGI YKKHPYLIQS AIDNEVCSKA DIFVGNSFST 360 FSSHIVFERT QKMMRMGSTS SCKNENEVDV QWPSYAYNIA AGESNGPQKW MTNMSDSSLR 420 VISYDSNAIS CLG* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11299 | O-FucT_plant | 0.001 | 203 | 370 | 180 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11298 | O-FucT-2 | 0.0002 | 162 | 369 | 225 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11302 | O-FucT-1 | 0.0002 | 195 | 369 | 200 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
cd11296 | O-FucT_like | 8.0e-20 | 193 | 370 | 182 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 5.0e-22 | 76 | 370 | 326 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_187183.3 | 0 | 19 | 431 | 16 | 442 | unknown protein [Arabidopsis thaliana] |
RefSeq | XP_002273827.1 | 0 | 23 | 431 | 4 | 427 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321799.1 | 0 | 87 | 431 | 1 | 347 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002332132.1 | 0 | 87 | 431 | 1 | 347 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531235.1 | 0 | 1 | 431 | 1 | 446 | conserved hypothetical protein [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3zy6_A | 0.0003 | 244 | 366 | 212 | 340 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3zy5_A | 0.0003 | 244 | 366 | 212 | 340 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3zy4_A | 0.0003 | 244 | 366 | 212 | 340 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3zy3_B | 0.0003 | 244 | 366 | 212 | 340 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3zy3_A | 0.0003 | 244 | 366 | 212 | 340 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |