| Basic Information | |
|---|---|
| Species | Gossypium raimondii |
| Cazyme ID | Gorai.N009300.1 |
| Family | GH79 |
| Protein Properties | Length: 526 Molecular Weight: 57891.8 Isoelectric Point: 6.8369 |
| Chromosome | Chromosome/Scaffold: 20 Start: 120790 End: 123216 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 38 | 519 | 0 |
| DDNFVCATLDWWPTEKCNYNQCPWGKAGILNLDLKMKGLINAVKAFNPLRIKIGGSLQDQVVYGVGGVKNCPNFIKNEDSLFGFSQGCLPMERWDQLNNF FNQTGVKVTFGLNALLGRNRSEIEKGLWVGDWQSQNAGDFMKYTISKGYKVDSYEFGNQLSGAGMGASVEAEQYGKDIVVLKNLVKELHPDPKTQPKVLG PSGYYDEKWFNSFLEVSGHDVVDGVTHHIYNLGPGDDPNMIAKIQDPSYLNQVSQTYKGVLNIVNKFKPQSGAWVSESGGALHGGAKDLSPTFADGFWYL DQLGMASTYNQKVFCRQTLIGGNYALLNTTTSIPNPDYYGALLWHRLMGSTVLAVTQESNPNLRVYANCAKKKPGISIIFINLSKDSSFNVTLSNYEHQG RNLRSTDVVKPNFEFRGSKDREEYHLAALAGNIRGQIVLLNDVPMVPTETFDIPAVEPKLVNASTPIHIAAHSIVYVTIRDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 526 Download |
| MDLKCIFSLA ILVSQISLSS TQNVNVVIQG ATPIAETDDN FVCATLDWWP TEKCNYNQCP 60 WGKAGILNLD LKMKGLINAV KAFNPLRIKI GGSLQDQVVY GVGGVKNCPN FIKNEDSLFG 120 FSQGCLPMER WDQLNNFFNQ TGVKVTFGLN ALLGRNRSEI EKGLWVGDWQ SQNAGDFMKY 180 TISKGYKVDS YEFGNQLSGA GMGASVEAEQ YGKDIVVLKN LVKELHPDPK TQPKVLGPSG 240 YYDEKWFNSF LEVSGHDVVD GVTHHIYNLG PGDDPNMIAK IQDPSYLNQV SQTYKGVLNI 300 VNKFKPQSGA WVSESGGALH GGAKDLSPTF ADGFWYLDQL GMASTYNQKV FCRQTLIGGN 360 YALLNTTTSI PNPDYYGALL WHRLMGSTVL AVTQESNPNL RVYANCAKKK PGISIIFINL 420 SKDSSFNVTL SNYEHQGRNL RSTDVVKPNF EFRGSKDREE YHLAALAGNI RGQIVLLNDV 480 PMVPTETFDI PAVEPKLVNA STPIHIAAHS IVYVTIRDFQ APACA* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 8.0e-170 | 22 | 341 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI27258.1 | 0 | 21 | 524 | 24 | 523 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 21 | 524 | 22 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 17 | 525 | 19 | 518 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0.0000000000003 | 6 | 99 | 476 | 587 | Heparanase precursor, putative [Ricinus communis] |
| RefSeq | XP_002512114.1 | 0 | 24 | 523 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000001 | 129 | 423 | 119 | 403 | A Chain A, The Structure Of A Protein In Glycosyl Transferase Family 8 From Anaerococcus Prevotii. |
| PDB | 3vnz_A | 0.000001 | 129 | 423 | 119 | 403 | A Chain A, The Structure Of A Protein In Glycosyl Transferase Family 8 From Anaerococcus Prevotii. |
| PDB | 3vny_A | 0.000001 | 129 | 423 | 119 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
