Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.N016700.1 |
Family | GH79 |
Protein Properties | Length: 508 Molecular Weight: 57213.3 Isoelectric Point: 7.3613 |
Chromosome | Chromosome/Scaffold: 135 Start: 8732 End: 10953 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 38 | 508 | 0 |
DEDFICVTLDWWPTNKCDYDQCPWGQAGLFNLDLKNKILEKAVKAFHPLRIRVGGSLQDQVVYNVRNNIENCQPFQKQDKGFLFGFSIGCLDMKRWDELN EFFNQTRAKVTFGLNALIGRKESETEKTLWVGDWYSHNARDLMSYTISKGYKIDSYELGNELCGVGVSARIEAKQYAKDMATLKNLVKEMYPNPKTQPKV LGPGGFYDKKWFDTFLDASGHDVIDGVTHHIYNLGPGNNPNVVHRVQDPFFLTQIAQTFKDVSNAIDKFAPWSGAWVSESGGAYNSGGQLVSYTFAFGFW YLDQLGMTSVYNHKVYCRQALTGGNYALLNTTTFVPNPDYYGALLWHRVMGSKVLSVMHKGSPYLRVYSHCAKKEAGVSFVFINLSKNTSFEIDLFHDLN LNGGSPNFEFKGHKKREEYHLIPKDGNILSSIVLLNGTPLELSDSLEIPELKPKLVDGLKPISIATHSIAF |
Full Sequence |
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Protein Sequence Length: 508 Download |
MNFRSITFFV VLLSCLLVSK AEKVEVVVEG ATPIAQTDED FICVTLDWWP TNKCDYDQCP 60 WGQAGLFNLD LKNKILEKAV KAFHPLRIRV GGSLQDQVVY NVRNNIENCQ PFQKQDKGFL 120 FGFSIGCLDM KRWDELNEFF NQTRAKVTFG LNALIGRKES ETEKTLWVGD WYSHNARDLM 180 SYTISKGYKI DSYELGNELC GVGVSARIEA KQYAKDMATL KNLVKEMYPN PKTQPKVLGP 240 GGFYDKKWFD TFLDASGHDV IDGVTHHIYN LGPGNNPNVV HRVQDPFFLT QIAQTFKDVS 300 NAIDKFAPWS GAWVSESGGA YNSGGQLVSY TFAFGFWYLD QLGMTSVYNH KVYCRQALTG 360 GNYALLNTTT FVPNPDYYGA LLWHRVMGSK VLSVMHKGSP YLRVYSHCAK KEAGVSFVFI 420 NLSKNTSFEI DLFHDLNLNG GSPNFEFKGH KKREEYHLIP KDGNILSSIV LLNGTPLELS 480 DSLEIPELKP KLVDGLKPIS IATHSIAF |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 8.0e-172 | 30 | 343 | 314 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 7 | 508 | 8 | 512 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 7 | 508 | 6 | 510 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 5 | 508 | 7 | 506 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 21 | 508 | 28 | 519 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.000000000000005 | 27 | 99 | 503 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00000001 | 134 | 406 | 122 | 383 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3vnz_A | 0.00000001 | 134 | 406 | 122 | 383 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3vny_A | 0.00000001 | 134 | 406 | 122 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |