| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os02g55870.1 |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 58871.7 Isoelectric Point: 6.4437 |
| Chromosome | Chromosome/Scaffold: 2 Start: 34199419 End: 34203705 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 51 | 535 | 0 |
| DEDFVCATLDWWPPDKCDYGTCSWGLATLLNMDLSNKILLNAVKAFSPLKLRLGGSLQDVLIYDTGDPRQPCTPFTKNSSAMFGFTQGCLPLHRWDELNA FFQKSGAKIIFGLNALNGRVPMSDDSLGGPWNYTNAASFIRYTVSKGYDIHGWELGNELSGSGVGARVDADQYAQDVLALKQIIDNSYQGHASKPLVIAP GGFFDAAWFTELISRTKPNQMDVMTHHIYNLGPGVDTHLIDKILDPSYLDGEAGTFSSLQGILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWYLD QLGMSSKYDTKTYCRQTLIGGNYGLLNTTTFEPNPDYYSALLWNRLMGTKVLSATFNGTNKIRAYAHCARDSRGITLLLINLSGNNTNHIYVTSEGVQPY STKKEGRRRFGRIPGLGEEAQLIREEYHLTPKDGSLQSQHVLLNGNVLAPDANGEIPKLEPVQVEGTQPITVAPYSIVFAHIPRF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MAAGLLLKLV GFCFWAVFWL GGAATVSTNA GGEAAAAAVV VDARSAIAVT DEDFVCATLD 60 WWPPDKCDYG TCSWGLATLL NMDLSNKILL NAVKAFSPLK LRLGGSLQDV LIYDTGDPRQ 120 PCTPFTKNSS AMFGFTQGCL PLHRWDELNA FFQKSGAKII FGLNALNGRV PMSDDSLGGP 180 WNYTNAASFI RYTVSKGYDI HGWELGNELS GSGVGARVDA DQYAQDVLAL KQIIDNSYQG 240 HASKPLVIAP GGFFDAAWFT ELISRTKPNQ MDVMTHHIYN LGPGVDTHLI DKILDPSYLD 300 GEAGTFSSLQ GILKSAGTST VAWVGEAGGA YNSGHHLVTD AFVFSFWYLD QLGMSSKYDT 360 KTYCRQTLIG GNYGLLNTTT FEPNPDYYSA LLWNRLMGTK VLSATFNGTN KIRAYAHCAR 420 DSRGITLLLI NLSGNNTNHI YVTSEGVQPY STKKEGRRRF GRIPGLGEEA QLIREEYHLT 480 PKDGSLQSQH VLLNGNVLAP DANGEIPKLE PVQVEGTQPI TVAPYSIVFA HIPRFYAPAC 540 R* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 50 | 353 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005618 | cell wall |
| GO:0008150 | biological_process |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY87898.1 | 0 | 1 | 541 | 1 | 541 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
| GenBank | EAY99897.1 | 0 | 9 | 540 | 7 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| RefSeq | NP_001048420.1 | 0 | 1 | 541 | 1 | 541 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001056967.1 | 0 | 9 | 540 | 7 | 525 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002452991.1 | 0 | 1 | 540 | 1 | 539 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0001 | 146 | 435 | 122 | 403 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
| PDB | 3vnz_A | 0.0001 | 146 | 435 | 122 | 403 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
| PDB | 3vny_A | 0.0001 | 146 | 435 | 122 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
