| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os03g11320.1 |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 60359.6 Isoelectric Point: 8.1452 |
| Chromosome | Chromosome/Scaffold: 3 Start: 5823515 End: 5828114 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 43 | 535 | 0 |
| KNYICATIDWWPPEKCNYNQCPWGQSSILNLDLDHPFLAQAIQAFDNLRIRLGGSLQDRVVYDVGTNSPCAPFTNMSNGLFGFSDGCLSMDRWDKLNALF QKTGAIITFGLNALYGRYNVRRSFWASKWNSTNAYNFVKYTISKGYPVDSWEYGNELSGHGIGARVDATLYGKDAIELKSIFQQLYKAPLSQPSLLAPGG FFDQQWYTQLLQTSGHGVVSALTHHIYNLGGGNDAHLIRKILDPKYLDRSEDTYRDMQLTLQRHGTWASAWVSESGGVFNNGGELVSNTFINSIWYLDQL GMASKYNTKIFCRQTLIGGHYGLLDTQTFLPNPDYYSALLWHRLMGREVLSVDINAPRKLRAYAHCRKQQQGITLLLINLSNTTGYNVTLQNDINVSLDK TASLHKHNSFSHSLRRAVSWLGRKPSSDVARREEYHLTAKDGDLQSKTMLLNGAPLELSDDGGVPAMSPALVAVNSPVYLAPTSIAFVVLPMF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MEVRLLLLVF ICLHALLWAA SAQQPEEATV IVKGSTKIAE TNKNYICATI DWWPPEKCNY 60 NQCPWGQSSI LNLDLDHPFL AQAIQAFDNL RIRLGGSLQD RVVYDVGTNS PCAPFTNMSN 120 GLFGFSDGCL SMDRWDKLNA LFQKTGAIIT FGLNALYGRY NVRRSFWASK WNSTNAYNFV 180 KYTISKGYPV DSWEYGNELS GHGIGARVDA TLYGKDAIEL KSIFQQLYKA PLSQPSLLAP 240 GGFFDQQWYT QLLQTSGHGV VSALTHHIYN LGGGNDAHLI RKILDPKYLD RSEDTYRDMQ 300 LTLQRHGTWA SAWVSESGGV FNNGGELVSN TFINSIWYLD QLGMASKYNT KIFCRQTLIG 360 GHYGLLDTQT FLPNPDYYSA LLWHRLMGRE VLSVDINAPR KLRAYAHCRK QQQGITLLLI 420 NLSNTTGYNV TLQNDINVSL DKTASLHKHN SFSHSLRRAV SWLGRKPSSD VARREEYHLT 480 AKDGDLQSKT MLLNGAPLEL SDDGGVPAMS PALVAVNSPV YLAPTSIAFV VLPMFEAKAC 540 S* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 343 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005618 | cell wall |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 20 | 541 | 20 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACV84153.1 | 0 | 1 | 541 | 1 | 542 | heparanase [Oryza sativa Indica Group] |
| GenBank | EAZ26032.1 | 0 | 1 | 541 | 1 | 497 | hypothetical protein OsJ_09885 [Oryza sativa Japonica Group] |
| RefSeq | NP_001049350.1 | 0 | 1 | 541 | 1 | 541 | Os03g0211700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002468296.1 | 0 | 11 | 541 | 14 | 543 | hypothetical protein SORBIDRAFT_01g043180 [Sorghum bicolor] |
