| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os04g52630.1 |
| Family | CBM57 |
| Protein Properties | Length: 949 Molecular Weight: 104058 Isoelectric Point: 8.0896 |
| Chromosome | Chromosome/Scaffold: 4 Start: 31308749 End: 31316299 |
| Description | Leucine-rich repeat transmembrane protein kinase |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| CBM57 | 386 | 559 | 3.2e-28 |
| FAVNCGSNRSISGSDNYVYQADGVSLGAAQYYVTGETKWGVSNIGKFMDAPSNGIYIFNSSRQFQSTLDPELFQTARLSPSSLRYYGIGLENGNYTVTLQ FAEIEFEDTKSWKSLGRRVFDIYIQGERKERNFDIRKATGGKSYTAVKKQYLIPVTKNFVEIHLFWAGKGTCCI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 949 Download |
| MRRFIRSRVR RQIHLHGSVL LIILLLLAAA VAQAQQAPTT RTDPTEAAAL NAVFAKLGQK 60 AQPSWNITGD PCTGRATDGS STEDDSFNPA ITCDCTDQNG TVCHITKLKI YAMDASGPIP 120 EELRNLTRLT NLNFGINALS GSIPKEFGNL TNLISLGLGS NNFSGPLPSE LGNLDKLTGL 180 YIDSAGLSGE LPSSFSKLTK VEKLWASDNN FTGKIPDYIG SWNLTDLRFQ GNSFQGSIPA 240 TLSKLVQLTN LRIGDIENGS SSLAFISNMT SLSILVLRNC KISDNLASID FSKFASLKLL 300 DLSFNNITGQ VPEAMLGLNS LNFLDFSYNQ LSGNFPSWAN EKNLQLNLVA NNFVLDNSNN 360 SVLPSGLECL QRNTPCFLGS PHSASFAVNC GSNRSISGSD NYVYQADGVS LGAAQYYVTG 420 ETKWGVSNIG KFMDAPSNGI YIFNSSRQFQ STLDPELFQT ARLSPSSLRY YGIGLENGNY 480 TVTLQFAEIE FEDTKSWKSL GRRVFDIYIQ GERKERNFDI RKATGGKSYT AVKKQYLIPV 540 TKNFVEIHLF WAGKGTCCIP AQGYYGPSIS ALSLKPNFIP TVRSAAAQRK SSSKTGVIVG 600 VVVGVAVFGL VALAAIFLWM QKRRKLSLEQ QELYCIVGRP NVFSYGQLRS ATENFNFSNR 660 LGEGGYGAVY KGKLTDGRVV AVKQLSQTSN QGKQQFATEI ETISRVQHRT EKLNIDWPAR 720 FEICLGIARG LAYLHEESSI RVIHRDIKAS NVLLDANLNP KISDFGLAKL YDDKKTHVST 780 KVAGTFGYLA PEYAMRGRMT EKVDVFAFGV VLLEILAGRP NYDDALEEDK IYIFEWAWDL 840 YENNNPLGLV DPKLEEFNRE EVLRAIRVAL LCTQGSPHQR PPMSRVVTML AGDVEAPEVV 900 TKPSYITEWQ LKGGDTSYLD SEVSWQSSSA PGGPASPRTS SPFLSSVD* 960 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00220 | S_TKc | 7.0e-37 | 655 | 832 | 213 | + Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. | ||
| smart00219 | TyrKc | 2.0e-37 | 657 | 890 | 274 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| cd00180 | PKc | 1.0e-37 | 661 | 815 | 191 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
| pfam00069 | Pkinase | 3.0e-38 | 660 | 835 | 211 | + Protein kinase domain. | ||
| pfam11721 | Malectin | 2.0e-60 | 385 | 572 | 190 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0000166 | nucleotide binding |
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0005886 | plasma membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAD41885.2 | 0 | 33 | 948 | 33 | 948 | OSJNBa0093O08.4 [Oryza sativa (japonica cultivar-group)] |
| EMBL | CAJ86064.1 | 0 | 29 | 948 | 842 | 1770 | H0818E11.1 [Oryza sativa (indica cultivar-group)] |
| EMBL | CAJ86064.1 | 0 | 36 | 947 | 18 | 825 | H0818E11.1 [Oryza sativa (indica cultivar-group)] |
| GenBank | EEC78008.1 | 0 | 33 | 930 | 33 | 915 | hypothetical protein OsI_17411 [Oryza sativa Indica Group] |
| GenBank | EEE61689.1 | 0 | 33 | 948 | 33 | 908 | hypothetical protein OsJ_16162 [Oryza sativa Japonica Group] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ulz_A | 0 | 637 | 893 | 14 | 309 | A Chain A, Crystal Structure Of The Nasturtium Seedling Mutant Xyloglucanase Isoform Nxg1-Delta-Yniig |
| PDB | 3uim_A | 0 | 637 | 893 | 14 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3tl8_H | 0 | 637 | 893 | 22 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_G | 0 | 637 | 893 | 22 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_D | 0 | 637 | 893 | 22 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
