| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os04g55730.1 |
| Family | GH89 |
| Protein Properties | Length: 797 Molecular Weight: 90854.4 Isoelectric Point: 6.0527 |
| Chromosome | Chromosome/Scaffold: 4 Start: 33170208 End: 33179341 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 99 | 440 | 0 |
| PQVLLLGTSGVEISAGLHWYLKHYCAAHVSWDKTGGAQLSSVPRPGSLPRLPSGGILIQRPVGWSYYQNAVTSSYSFAWWDWERWEKEIDWMALQGINLP LAFTGQEAIWQKVFQRYNISKSDLDDFFGGPAFLAWSRMANMHGWGGPLPQSWLDDQLALQKKILSRMYAFGMFPVLPAFSGNIPAALRSKFPSAKVTHL GNWFTVDSNPRWCCTYLLDASDPLFVEIGKLFIEEQIREYGGTSHVYSCDTFDENTPPLSDPNYISSLGAATFRGMQSGDDDAIWLMQGWLFSYDPFWEP PQMKALLHSVPVGRMIVLDLYAEVKPIWINSDQFYGVPYIWK | |||
| GH89 | 441 | 772 | 0 |
| VGVGMSMEGIEQNPIVYDLMSEMAFHHRQVDLQVWVETYPTRRYGKSMVGLQDAWKILYQTLYNCTDGKNDKNRDVIVAFPDVEPFVIQTPGLYTSSSKT YSTKLSKNYIAVDASNDEYEHPHLWYDTDAVIRALELFLRYGDEVSDSNTFRYDLVDLTRQTLAKYANQVFVKIIESYKSNNVNQVSNLCQHFIDLVNDL DTLLASHEGFLLGPWLESAKGLARDKEQEMQYEWNARTQITMWFDNTKTKASLLRDYANKYWSGLLRDYYGPRAAIYFKYLILSMEKKEPFALEEWRREW ISLTNNWQSDWKVFPTTATGDALNISRTLYKK | |||
| Full Sequence |
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| Protein Sequence Length: 797 Download |
| MPAPRLLRVL LLLVALACAT SGVGCSDPRF PHLGRVRELH RGEGRPAAEQ EAAARGLLAL 60 LLPSHSGSFD FRVISADQCG GKACFIVDNH PLFDGEGTPQ VLLLGTSGVE ISAGLHWYLK 120 HYCAAHVSWD KTGGAQLSSV PRPGSLPRLP SGGILIQRPV GWSYYQNAVT SSYSFAWWDW 180 ERWEKEIDWM ALQGINLPLA FTGQEAIWQK VFQRYNISKS DLDDFFGGPA FLAWSRMANM 240 HGWGGPLPQS WLDDQLALQK KILSRMYAFG MFPVLPAFSG NIPAALRSKF PSAKVTHLGN 300 WFTVDSNPRW CCTYLLDASD PLFVEIGKLF IEEQIREYGG TSHVYSCDTF DENTPPLSDP 360 NYISSLGAAT FRGMQSGDDD AIWLMQGWLF SYDPFWEPPQ MKALLHSVPV GRMIVLDLYA 420 EVKPIWINSD QFYGVPYIWK VGVGMSMEGI EQNPIVYDLM SEMAFHHRQV DLQVWVETYP 480 TRRYGKSMVG LQDAWKILYQ TLYNCTDGKN DKNRDVIVAF PDVEPFVIQT PGLYTSSSKT 540 YSTKLSKNYI AVDASNDEYE HPHLWYDTDA VIRALELFLR YGDEVSDSNT FRYDLVDLTR 600 QTLAKYANQV FVKIIESYKS NNVNQVSNLC QHFIDLVNDL DTLLASHEGF LLGPWLESAK 660 GLARDKEQEM QYEWNARTQI TMWFDNTKTK ASLLRDYANK YWSGLLRDYY GPRAAIYFKY 720 LILSMEKKEP FALEEWRREW ISLTNNWQSD WKVFPTTATG DALNISRTLY KKYLHDADLI 780 QPEGIIRLRN LKNTPW* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-18 | 63 | 149 | 87 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-106 | 475 | 773 | 299 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 2.0e-161 | 164 | 469 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0000003 | reproduction |
| GO:0005773 | vacuole |
| GO:0008152 | metabolic process |
| GO:0009791 | post-embryonic development |
| GO:0016787 | hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAE04506.2 | 0 | 1 | 796 | 1 | 829 | OSJNBb0059K02.16 [Oryza sativa (japonica cultivar-group)] |
| EMBL | CAJ86183.1 | 0 | 1 | 701 | 1 | 687 | H0212B02.15 [Oryza sativa (indica cultivar-group)] |
| GenBank | EEC78143.1 | 0 | 1 | 796 | 1 | 829 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 22 | 796 | 322 | 1129 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 32 | 779 | 30 | 810 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 77 | 763 | 196 | 866 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 2vcb_A | 0 | 77 | 763 | 196 | 866 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 2vca_A | 0 | 77 | 763 | 196 | 866 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 2vc9_A | 0 | 77 | 763 | 196 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 77 | 763 | 219 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
