| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os05g16430.1 |
| Family | CBM57 |
| Protein Properties | Length: 844 Molecular Weight: 93345.2 Isoelectric Point: 7.1843 |
| Chromosome | Chromosome/Scaffold: 5 Start: 9321701 End: 9328355 |
| Description | Leucine-rich repeat transmembrane protein kinase |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| CBM57 | 256 | 426 | 1.8e-24 |
| FAVDCGSNSSTRGSDNTIYEAEPTNLGDASYYVTSQTRWGVSNVGKFSLASNGMNIISSSEHFQNAVNSRLFETARMSPSSLRYYGLGLENGNYTILLQF AEVAYPDSQTWQSLGRRVFDIYIQGSLREKDFDIRKMAGGKSFIVVHRSYTATVSNNFLEIHLFWAGKGTC | |||
| Full Sequence |
|---|
| Protein Sequence Length: 844 Download |
| MSWQRVGALL LGAQSCLPVP GVPAVGGIGG LALNPLSGLL PKELGNLTNL LSLGISLDNF 60 TGELPEELGN LTKLQQLYID SSGFSGPFPP TFSKLKNLNT LRASDNEFTG KIPDYLGSLT 120 NLIDLILRNC KVSGNLGPVD FSMFTALILL DLSFNNITGE VPQSILNMGK LEFLDFSYNQ 180 LTGNFPSWAT QNNLQLNLVA NKFDAGSNNR SKTLLVFVDL QNVFIFLFFK DCSSQHDFRN 240 FKNNGYVFHI LTDYSFAVDC GSNSSTRGSD NTIYEAEPTN LGDASYYVTS QTRWGVSNVG 300 KFSLASNGMN IISSSEHFQN AVNSRLFETA RMSPSSLRYY GLGLENGNYT ILLQFAEVAY 360 PDSQTWQSLG RRVFDIYIQG SLREKDFDIR KMAGGKSFIV VHRSYTATVS NNFLEIHLFW 420 AGKGTCCIPT NGYYGPMISA LSVSPNFTPT VRNGVPKRRS KVHTIAGILI GASILGLAAL 480 FGIFMMVKKR RTMAQQKEEL YNLIGRPDVF SNTELRLATD NFSSQNILGE GGYGMLYKGK 540 LSDGRVIAVK QLSQSSHQGK SQFVAEVTTI SAMQHRNLVK LHGFCIDSNT PLLVYEYLQN 600 GSLDTALFGH SRLNLDWGTR FNIILGIASG LTYLHEESSV RIVHRDIKAS NILLETDLTP 660 KISDFGLAKL YDEKQTHVST RIAGTLGYLA PEYAMRGRLT EKVDVFAFGV VVLEIVAGRS 720 NTNNSLEESK IYLFEWLWDL YEKEQVLGIV DPSLKDFNNN EAFRVIRVAL LCTQGSPHQR 780 PPMSKALAML TGEVELSEVV VKPSYITEWQ LRDVNRSYAT SSYSGSTNPE FSTQKEIEPL 840 TQS* 900 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00069 | Pkinase | 2.0e-44 | 527 | 735 | 213 | + Protein kinase domain. | ||
| smart00219 | TyrKc | 6.0e-46 | 527 | 715 | 195 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| smart00221 | STYKc | 6.0e-46 | 527 | 715 | 195 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
| cd00180 | PKc | 1.0e-47 | 528 | 715 | 192 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
| pfam11721 | Malectin | 1.0e-54 | 254 | 441 | 189 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0000166 | nucleotide binding |
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0005886 | plasma membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EEC78858.1 | 0 | 30 | 843 | 153 | 1015 | hypothetical protein OsI_19210 [Oryza sativa Indica Group] |
| GenBank | EEC78858.1 | 0.0000000002 | 38 | 187 | 113 | 261 | hypothetical protein OsI_19210 [Oryza sativa Indica Group] |
| GenBank | EEC78858.1 | 0.00000002 | 47 | 188 | 98 | 238 | hypothetical protein OsI_19210 [Oryza sativa Indica Group] |
| GenBank | EEE63012.1 | 0 | 174 | 843 | 103 | 752 | hypothetical protein OsJ_17820 [Oryza sativa Japonica Group] |
| RefSeq | XP_002444009.1 | 0 | 31 | 843 | 159 | 998 | hypothetical protein SORBIDRAFT_07g005820 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ulz_A | 0 | 494 | 793 | 6 | 309 | A Chain A, Structure Of Endo-Beta-N-Acetylglucosaminidase A |
| PDB | 3uim_A | 0 | 494 | 793 | 6 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3tl8_H | 0 | 494 | 793 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_G | 0 | 494 | 793 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_D | 0 | 494 | 793 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
